Reactome | DOK1 [cytosol]

DOK1 [cytosol]

Stable Identifier

R-HSA-74763

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Docking protein 1, p62(dok), Downstream of tyrosine kinase 1, pp62

Locations in the PathwayBrowser for interactor UniProt:Q9Q2G4 Q9Q2G4

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External Reference Information

External Reference

UniProt:Q99704 DOK1

Gene Names

DOK1

Chain

chain:1-481

Reference Genes

BioGPS Gene:1796 DOK1

COSMIC (genes):DOK1 DOK1

CTD Gene:1796 DOK1

dbSNP Gene:1796 DOK1

ENSEMBL:ENSG00000115325 DOK1

HGNC:2990 DOK1

KEGG:hsa:1796 DOK1

Monarch:1796 DOK1

NCBI Gene:1796 DOK1

OMIM:602919 DOK1

UCSC:Q99704 DOK1

Reference Transcript

Other Identifiers

11731530_a_at

11731531_x_at

11747949_a_at

11751046_a_at

11763329_a_at

16881802

1796

211121_PM_s_at

211121_s_at

216835_PM_s_at

216835_s_at

2489441

2489445

2489446

2489447

2489448

2489449

2489450

2489451

2489452

2489453

2489454

2489455

2489456

2489457

34433_at

8042917

815_at

816_g_at

A_14_P123412

A_23_P5601

A_23_P5610

GE54274

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0007165

GO:0007166

GO:0007169

GO:0007265

GO:0035556

GO:0038145

GO:0043226

GO:0043410

GO:0048471

HMNXSV003022393

HMNXSV003051301

ILMN_1700086

PH_hs_0005763

TC02000464.hg

U70987_at

g6606314_3p_a_at

Participates

as a member of

DOK1,DOK2,DOK4,DOK5,DOK6 [cytosol] (Homo sapiens)

as a component of

p-Y342-PTK6:DOK1 [cytosol] (Homo sapiens)

as an input of

PTK6 binds DOK1 (Homo sapiens)

Other forms of this molecule

p-Y362-DOK1 [cytosol]

Inferred To

Dok1 [cytosol] (Mus musculus)

Dok1 [cytosol] (Rattus norvegicus)

rog-1 [cytosol] (Caenorhabditis elegans)

dok1b [cytosol] (Danio rerio)

DOK1 [cytosol] (Bos taurus)

DOK1 [cytosol] (Canis familiaris)

DOK1 [cytosol] (Gallus gallus)

DOK1 [cytosol] (Sus scrofa)

Dok [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001305797.1, NP_001372.1, NP_001184189.1

ENSEMBL

ENST00000233668, ENSP00000344330, ENST00000340004, ENSP00000387016, ENSP00000233668, ENST00000409429

OpenTargets

ENSG00000115325

HPA

ENSG00000115325-DOK1

PRO

Q99704

Pharos - Targets

Q99704

PDB

2V76

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H3Y6 SRMS	1	SRMS [cytosol] (R-HSA-3902520)	0.639	7
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:Q9JIY2	1	Cbll1 [cytosol] (R-MMU-8851646)	0.524	2
UniProt:Q9Q2G4 Q9Q2G4			0.499	2
UniProt:Q7L591-3 DOK3			0.488	2
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.488	2
UniProt:O60880 SH2D1A	1	SH2D1A [cytosol] (R-HSA-5685108)	0.462	2

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