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TTF1 [nucleoplasm]
Stable Identifier
R-HSA-74974
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
TTF-1
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Negative epigenetic regulation of rRNA expression (Homo sapiens)
NoRC negatively regulates rRNA expression (Homo sapiens)
Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA (Homo sapiens)
TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
TTF-I binds to the Sal Box (Homo sapiens)
TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
Positive epigenetic regulation of rRNA expression (Homo sapiens)
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression (Homo sapiens)
Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene (Homo sapiens)
TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
TTF-I binds to the Sal Box (Homo sapiens)
TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9 (Homo sapiens)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
RNA Polymerase I Transcription (Homo sapiens)
RNA Polymerase I Promoter Clearance (Homo sapiens)
RNA Polymerase I Transcription Initiation (Homo sapiens)
Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Homo sapiens)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
RNA Polymerase I Transcription Termination (Homo sapiens)
Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box (Homo sapiens)
PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
RNA Polymerase I:rRNATranscript:TTF-1:Sal Box Complex [nucleoplasm] (Homo sapiens)
TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Homo sapiens)
PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
RNA Polymerase I:rRNATranscript:TTF-1:Sal Box Complex [nucleoplasm] (Homo sapiens)
TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
RNA Polymerase I:rRNATranscript:TTF-1:Sal Box Complex [nucleoplasm] (Homo sapiens)
TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box (Homo sapiens)
RNA Polymerase I:rRNATranscript:TTF-1:Sal Box Complex [nucleoplasm] (Homo sapiens)
TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
TTF-I binds to the Sal Box (Homo sapiens)
TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Surfactant metabolism (Homo sapiens)
CCDC59 binds TTF1 (Homo sapiens)
CCDC59:TTF1 [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
CCDC59:TTF1 binds SFTPB gene (Homo sapiens)
CCDC59:TTF1 [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
CCDC59:TTF1:SFTPB gene [nucleoplasm] (Homo sapiens)
CCDC59:TTF1 [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
CCDC59:TTF1 binds SFTPC gene (Homo sapiens)
CCDC59:TTF1 [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
CCDC59:TTF1:SFTPC gene [nucleoplasm] (Homo sapiens)
CCDC59:TTF1 [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
SFTPB gene produces pro-SFTPB protein (Homo sapiens)
CCDC59:TTF1:SFTPB gene [nucleoplasm] (Homo sapiens)
CCDC59:TTF1 [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
SFTPC gene produces pro-SFTPC protein (Homo sapiens)
CCDC59:TTF1:SFTPC gene [nucleoplasm] (Homo sapiens)
CCDC59:TTF1 [nucleoplasm] (Homo sapiens)
TTF1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15361 TTF1
Gene Names
TTF1
Chain
chain:1-905
Reference Genes
BioGPS Gene:7270 TTF1
COSMIC (genes):TTF1 TTF1
CTD Gene:7270 TTF1
dbSNP Gene:7270 TTF1
ENSEMBL:ENSG00000125482 TTF1
HGNC:12397 TTF1
Monarch:7270 TTF1
NCBI Gene:7270 TTF1
OMIM:600777 TTF1
UCSC:Q15361 TTF1
Reference Transcript
RefSeq:XM_006717273.3 TTF1
RefSeq:NM_007344.3 TTF1
RefSeq:NM_001205296.1 TTF1
Other Identifiers
11733881_at
11733882_a_at
11733883_at
17099295
204771_PM_s_at
204771_s_at
204772_PM_s_at
204772_s_at
3228098
3228099
3228100
3228101
3228102
3228109
3228113
3228114
3228116
3228117
3228118
3228119
3228120
3228121
3228122
36478_at
7270
8164729
84505_r_at
A_23_P254031
A_33_P3230339
GE61068
GO:0001650
GO:0003677
GO:0003682
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0006353
GO:0006363
GO:0008156
GO:0043226
HMNXSV003011453
HMNXSV003021419
Hs.54780.0.S1_3p_a_at
ILMN_1713129
ILMN_2128133
PH_hs_0003596
TC09001674.hg
X83973_at
g6678454_3p_a_at
Participates
as an output of
Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box (Homo sapiens)
Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA (Homo sapiens)
as an input of
TTF-I binds to the Sal Box (Homo sapiens)
CCDC59 binds TTF1 (Homo sapiens)
as a component of
TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
CCDC59:TTF1 [nucleoplasm] (Homo sapiens)
Inferred To
Ghost homologue of TTF1 [nucleoplasm]
(Caenorhabditis elegans)
Ttf1 [nucleoplasm]
(Mus musculus)
Ttf1 [nucleoplasm]
(Rattus norvegicus)
ttf1 [nucleoplasm]
(Xenopus tropicalis)
TTF1 [nucleoplasm]
(Bos taurus)
TTF1 [nucleoplasm]
(Canis familiaris)
TTF1 [nucleoplasm]
(Gallus gallus)
TTF1 [nucleoplasm]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000334270
,
ENSP00000333920
OpenTargets
ENSG00000125482
HPA
ENSG00000125482-TTF1
PRO
Q15361
Pharos - Targets
Q15361
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22492 H1T
0.527
3
UniProt:P62888 RPL30
1
RPL30 [cytosol]
(R-HSA-72452)
0.527
2
UniProt:P42696 RBM34
0.527
3
UniProt:P50914 RPL14
1
RPL14 [cytosol]
(R-HSA-72414)
0.527
3
UniProt:Q02543 RPL18A
1
RPL18A [cytosol]
(R-HSA-72422)
0.527
2
UniProt:Q96HE9 PRR11
0.527
2
UniProt:P62263 RPS14
2
RPS14 [cytosol]
(R-HSA-72333)
RPS14 [nucleoplasm]
(R-HSA-6790669)
0.527
2
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