Phosphorylation of Cdc25C at Ser 216 by Chk1

Stable Identifier
R-HSA-75010
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylation of Cdc25C at Ser 216 by Chk1
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Phosphorylation of Cdc25C at Ser 216 results in both the inhibition of Cdc25C phosphatase activity and the creation of a 14-3-3 docking site (Peng et al. 1997).

Literature References
PubMed ID Title Journal Year
9278512 Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216.

Piwnica-Worms, H, Shaw, AS, Thoma, RS, Peng, CY, Wu, Z, Graves, PR

Science 1997
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]

Physical Entity
p-S317,S345-CHEK1 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of Cdc25C at Ser 216 by Chk1 (Caenorhabditis elegans)
Phosphorylation of Cdc25C at Ser 216 by Chk1 (Canis familiaris)
Phosphorylation of Cdc25C at Ser 216 by Chk1 (Danio rerio)
Phosphorylation of Cdc25C at Ser 216 by Chk1 (Drosophila melanogaster)
Phosphorylation of Cdc25C at Ser 216 by Chk1 (Mus musculus)
Phosphorylation of Cdc25C at Ser 216 by Chk1 (Rattus norvegicus)
Phosphorylation of Cdc25C at Ser 216 by Chk1 (Saccharomyces cerevisiae)
Phosphorylation of Cdc25C at Ser 216 by Chk1 (Schizosaccharomyces pombe)
Phosphorylation of Cdc25C at Ser 216 by Chk1 (Sus scrofa)
Authored
Matthews, L  (2003-08-05)
Created
Matthews, L  (2003-08-05)
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