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Phosphorylation of Wee1 kinase by Chk1
Stable Identifier
R-HSA-75028
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Cell Cycle (Homo sapiens)
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G2/M DNA damage checkpoint (Homo sapiens)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Homo sapiens)
Phosphorylation of Wee1 kinase by Chk1 (Homo sapiens)
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Phosphorylation of Wee1 by Chk1 stimulates Wee1 kinase activity.
Participants
Input
ATP [nucleoplasm]
WEE1 [nucleoplasm]
(Homo sapiens)
Output
ADP [nucleoplasm]
p-WEE1 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Homo sapiens)
Catalyst Activity
protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]
Physical Entity
p-S317,S345-CHEK1 [nucleoplasm]
(Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Phosphorylation of Wee1 kinase by Chk1 (Schizosaccharomyces pombe)
Authored
Matthews, L (2003-08-08)
Created
Matthews, L (2003-08-05)
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