Reactome | Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13

Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13

Stable Identifier

R-HSA-751027

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13

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About 25 receptors are reported to couple to the G12/13 G protein subtype (Riobo & Manning, 2005).Direct assay methods have not identified a receptor that only couples with G12. At least one receptor (5-HT4) only couples with G13, but most other receptors are reported to couple with both G12 and G13.

Literature References

PubMed ID	Title	Journal	Year
15749160	Receptors coupled to heterotrimeric G proteins of the G12 family Manning, DR, Riobo, NA	Trends Pharmacol Sci	2005
18374420	Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology Nakahata, N	Pharmacol Ther	2008
12433842	Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy Nishida, M, Kozasa, T, Tanabe, S, Nagao, T, Sugimoto, Y, Kurose, H, Maruyama, Y, Wada, T, Turner, JH	Circ Res	2002