TRAIL binds TRAIL receptors

Stable Identifier
Reaction [binding]
Homo sapiens
TNFSF10 binds TNFRSF10A or TNFRSF10B, TRAIL Binds TRAIL Receptor-1 or TRAIL Receptor-2, TRAIL binds DR4 or DR5
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TRAIL (TNF-related apoptosis-inducing ligand) binds TRAIL receptor-1 (TNFRSF10A) or TRAIL receptor-2 (TNFRSF10B) (Wiley et al. 1995, Pan et al. 1997, Walczak et al. 1997).

Literature References
PubMed ID Title Journal Year
9311998 TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL

Degli-Esposti, MA, Boiani, N, Waugh, JY, Goodwin, RG, Gerhart, MJ, Smolak, PJ, Johnson, RS, Schooley, KA, Timour, MS, Walczak, H, Smith, CA, Rauch, CT

EMBO J. 1997
8777713 Identification and characterization of a new member of the TNF family that induces apoptosis

Smolak, PJ, Rauch, C, Sutherland, GR, Huang, CP, Wiley, SR, Schooley, K, Smith, TD, Smith, CA, Nicholl, JK, Din, WS

Immunity 1995
9082980 The receptor for the cytotoxic ligand TRAIL

Ebner, R, Pan, G, O'Rourke, K, Dixit, VM, Chinnaiyan, AM, Gentz, R, Ni, J

Science 1997
Orthologous Events
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