Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta

Stable Identifier
R-HSA-75820
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta
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At the beginning of this reaction, 1 molecule of 'Cyclin D1:Cdk4', and 1 molecule of 'ATP' are present. At the end of this reaction, 1 molecule of 'phospho(T286)-Cyclin D1:Cdk4', and 1 molecule of 'ADP' are present.

This reaction takes place in the 'nucleus' and is mediated by the 'kinase activity' of 'glycogen synthase kinase-3 beta'.

Literature References
PubMed ID Title Journal Year
16732330 Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1

Herman, JG, Barbash, O, Lu, F, Zhang, F, Benzeno, S, Klein, PS, Diehl, JA, Guo, M, Rustgi, A

Oncogene 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of GSK3B [nucleoplasm]

Physical Entity
GSK3B [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Phosphorylation of Cyclin D1 on Thr-286 by GSK-3 beta (Mus musculus)
Created
Matthews, L  (2003-09-01)
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