Reactome | DHRS7B reduces GO3P to HXDG3P

DHRS7B reduces GO3P to HXDG3P

Stable Identifier

R-HSA-75883

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

O-hexadecylglycerone phosphate + NADPH + H+ => 1-hexadecyl glycerol-3-phosphate + NADP+, Conversion of acylated DHAP to lysophosphatidic acid

ReviewStatus

5/5

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DHRS7B (Dehydrogenase/reductase SDR family member 7B) catalyzes the reaction of NADPH and GO3P (O-hexadecyldihydroxyacetone phosphate) to form HXDG3P (1-hexadecyl glycerol-3-phosphate) and NADP+. The enzyme is associated with the outer face of the peroxisomal membrane; its substrates and products are thought to be cytosolic. The properties of the human enzyme are inferred from those of an activity purified from guinea pig liver (Datta et al. 1990). More recent studies of HXDG3P metabolism in cultured human cells in which DHRS7B activity was knocked down confirm the specificity of the human enzyme (Lodhi et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
2335525	Purification and properties of acyl/alkyl dihydroxyacetone-phosphate reductase from guinea pig liver peroxisomes Hajra, AK, Ghosh, MK, Datta, SC	J Biol Chem	1990
22863804	Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARγ activation to decrease diet-induced obesity Song, H, Funai, K, Baird, JH, El Ramahi, MK, Razani, B, Coleman, T, Semenkovich, CF, Fu-Hsu, F, Yin, L, Jensen-Urstad, AP, Turk, J, Lodhi, IJ	Cell Metab.	2012