1-acyl LPA is acylated to PA by AGPAT (LPAAT)

Stable Identifier
Reaction [transition]
Homo sapiens
1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, lysophosphatidic acid + fatty acyl CoA => phosphatidic acid + CoA (1)
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At the endoplasmic reticulum (ER) membrane, 1-acyl-lysophosphatidic acid (LPA) is acylated to phosphatidic acid (PA) by the enzymes 1-acyl-sn-glycerol-3-phosphate acyltransferases (AGPAT1 through 11), and lysophosphatidylcholine acyltransferase (LPCAT1) (Aguado and Campbell 1998).

See recent review by Agarwal (2012, in press).

AGPAT1, 2, 3 and LPCAT1 have been characterized biochemically (AGPAT1, 2: Yamashita et al. 2007, West et al. 1997, Aguado and Campbell 1998, Gale et al. 2006; AGPAT3: Agarwal et al. 2006; LPCAT1: Nakanishi et al. 2006, Chen et al. 2006). Two additional proteins, AGPAT4 and AGPAT5, are inferred to have such activity based on studies of homologous mouse enzymes (Lu et al. 2005). These enzymes differ in their tissue specific patterns of expression in the body and in their preferences for specific acyl CoA molecules (Shindou and Shimizu 2009; Takeuchi and Reue 2009).
Literature References
PubMed ID Title Journal Year
9212163 Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells

West, J, Coleman, J, Bursten, S, Nudelman, E, Kumar, A, Meengs, B, Tompkins, CK, Singer, JW, Leung, DW, White, T, Balantac, N

DNA Cell Biol 1997
16704971 Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production

Shindou, H, Suwabe, A, Ogasawara, R, Nakanishi, H, Taguchi, R, Shimizu, T, Harayama, T, Hishikawa, D

J Biol Chem 2006
9461603 Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex

Campbell, RD, Aguado, B

J Biol Chem 1998
15367102 Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart

Hatch, GM, Zhou, Y, Lu, B, Xu, FY, Jiang, YJ, Choy, PC

Biochem J 2005
16620771 Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity

Barnes, RI, Agarwal, AK, Garg, A

Arch Biochem Biophys 2006
22777291 Lysophospholipid acyltransferases: 1-acylglycerol-3-phosphate O-acyltransferases. From discovery to disease

Agarwal, AK

Curr. Opin. Lipidol. 2012
16864775 Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells

Chen, X, Mucenski, ML, Mason, RJ, Hyatt, BA, Shannon, JM

Proc Natl Acad Sci U S A 2006
17707131 Topology of acyltransferase motifs and substrate specificity and accessibility in 1-acyl-sn-glycero-3-phosphate acyltransferase 1

Waku, K, Tanaka, K, Nakanishi, H, Yamashita, A, Kamata, R, Sugiura, T, Suzuki, H

Biochim Biophys Acta 2007
19336658 Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis

Reue, K, Takeuchi, K

Am J Physiol Endocrinol Metab 2009
16495223 A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation

Gale, SE, Bowcock, A, Cao, L, Schaffer, JE, Frolov, A, Bickel, PE, Han, X, Ory, DS

J Biol Chem 2006
18718904 Acyl-CoA:lysophospholipid acyltransferases

Shindou, H, Shimizu, T

J Biol Chem 2009
Catalyst Activity

1-acylglycerol-3-phosphate O-acyltransferase activity of AGPAT [endoplasmic reticulum membrane]

Orthologous Events
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