Reactome | DHAP is converted to G3P by GPD1/GPD1L

DHAP is converted to G3P by GPD1/GPD1L

Stable Identifier

R-HSA-75889

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Dihydroxyacetone phosphate (DHAP) is converted to glycerol-3-phosphate (G3P) by glycerol-3-phosphate dehydrogenase (GPD1) or by glycerol-3-phosphate dehydrogenase-like (GPD1L) enzymes (Ou et al. 2006, Valdivia et al. 2009). The active forms of both enzymes are homodimers. This reaction may be found in white adipose tissues where glycerol-3-kinase activity is not observed in sufficient levels. GPD1/GPD1L reduces dihydroxyacetone phosphate with NADH donating electrons to this reduction.

Literature References

PubMed ID	Title	Journal	Year
16460752	Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1) Ou, X, Ji, C, Han, X, Zhao, X, Li, X, Mao, Y, Wong, LL, Bartlam, M, Rao, Z	J Mol Biol	2006
19666841	GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A Valdivia, CR, Ueda, K, Ackerman, MJ, Makielski, JC	Am J Physiol Heart Circ Physiol	2009