Reactome | Plasmalogen biosynthesis

Plasmalogen biosynthesis

Stable Identifier

R-HSA-75896

Type

Pathway

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

Synthesis of lysophosphatidic acid from dihydroxyacetone phosphate

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

1-Acylglycerol-3-phosphate is synthesized from dihydroxyacetone phosphate, an acyl CoA molecule and NADPH + H+ in four reactions catalyzed by peroxisomal enzymes, either in the matrix of the organelle or associated with its membrane. These reactions are annotated here for palmityl (C16:0) CoA. In a series of less well-characterized reactions in the cytosol and endoplasmic reticulum, these molecules are converted to ether lipids (plasmalogens). The functions of plasmalogens are not well understood. They are an abundant subclass of phospholipids, however, and defects in their metabolism are associated with serious human disease (de Vet et al. 1999; Nagan and Zoeller 2001).

Literature References

PubMed ID	Title	Journal	Year
10553003	Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities IJlst, L, Oostheim, W, van den Bosch, H, de Vet, EC, Dekker, C, Moser, HW	J Lipid Res	1999
11275267	Plasmalogens: biosynthesis and functions Zoeller, RA, Nagan, N	Prog Lipid Res	2001