Reactome | XRCC4 [nucleoplasm]

XRCC4 [nucleoplasm]

Stable Identifier

R-HSA-75911

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA repair protein XRCC4

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Nonhomologous End-Joining (NHEJ) (Homo sapiens)
    - POLL or POLM extends aligned DNA DSB ends to fill gaps (Homo sapiens)
      - p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Extended ligatable DNA DSB ends [nucleoplasm] (Homo sapiens)
        
        XRCC4:LIG4 [nucleoplasm] (Homo sapiens)
        
        XRCC4 homodimer [nucleoplasm] (Homo sapiens)
        
        XRCC4 [nucleoplasm] (Homo sapiens)
      - p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB ends [nucleoplasm] (Homo sapiens)
        
        XRCC4:LIG4 [nucleoplasm] (Homo sapiens)
        
        XRCC4 homodimer [nucleoplasm] (Homo sapiens)
        
        XRCC4 [nucleoplasm] (Homo sapiens)
    - XRCC4:LIG4 ligates DNA DSB ends during NHEJ (Homo sapiens)
      - XRCC4:LIG4 [nucleoplasm] (Homo sapiens)
        
        XRCC4 homodimer [nucleoplasm] (Homo sapiens)
        
        XRCC4 [nucleoplasm] (Homo sapiens)
      - p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Extended ligatable DNA DSB ends [nucleoplasm] (Homo sapiens)
        
        XRCC4:LIG4 [nucleoplasm] (Homo sapiens)
        
        XRCC4 homodimer [nucleoplasm] (Homo sapiens)
        
        XRCC4 [nucleoplasm] (Homo sapiens)
    - XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Homo sapiens)
      - XRCC4:LIG4 [nucleoplasm] (Homo sapiens)
        
        XRCC4 homodimer [nucleoplasm] (Homo sapiens)
        
        XRCC4 [nucleoplasm] (Homo sapiens)
      - p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB ends [nucleoplasm] (Homo sapiens)
        
        XRCC4:LIG4 [nucleoplasm] (Homo sapiens)
        
        XRCC4 homodimer [nucleoplasm] (Homo sapiens)
        
        XRCC4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13426 XRCC4

Gene Names

XRCC4

Chain

chain:1-336, chain:266-336

Reference Genes

BioGPS Gene:7518 XRCC4

COSMIC (genes):XRCC4 XRCC4

CTD Gene:7518 XRCC4

dbSNP Gene:7518 XRCC4

ENSEMBL:ENSG00000152422 XRCC4

ENSEMBL:ENSG00000152422.16 XRCC4

HGNC:12831 XRCC4

KEGG Gene (Homo sapiens):7518 XRCC4

Monarch:7518 XRCC4

NCBI Gene:7518 XRCC4

OMIM:194363 XRCC4

UCSC:Q13426 XRCC4

Reference Transcript

Other Identifiers

11725853_a_at

11741323_a_at

11744799_a_at

1360_at

16986895

205071_PM_x_at

205071_x_at

205072_PM_s_at

205072_s_at

210813_PM_s_at

210813_s_at

2818455

2818456

2818459

2818460

2818471

2818475

2818478

2818487

2818488

2818489

2818500

2818501

7518

8106730

A_14_P201832

A_23_P122174

GE62459

GO:0002376

GO:0003676

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005958

GO:0006281

GO:0006302

GO:0006303

GO:0006310

GO:0006974

GO:0010165

GO:0032807

GO:0033152

GO:0035861

GO:0042802

GO:0043226

GO:0048856

GO:0051103

GO:0051351

GO:0060090

GO:0070419

GO:0070975

GO:1990166

HMNXSV003032393

HMNXSV003051475

ILMN_2379695

PH_hs_0009095

TC05000411.hg

U40622_at

g12081904_3p_a_at

g12081904_3p_x_at

g12408646_3p_a_at

Participates

as an input of

PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Homo sapiens)

as a component of

XRCC4 homodimer [nucleoplasm] (Homo sapiens)

Other forms of this molecule

monoSUMO1-K210-XRCC4 [nucleoplasm]

Inferred To

Xrcc4 [nucleoplasm] (Mus musculus)

Xrcc4 [nucleoplasm] (Rattus norvegicus)

XRCC4 [nucleoplasm] (Bos taurus)

XRCC4 [nucleoplasm] (Canis familiaris)

XRCC4 [nucleoplasm] (Danio rerio)

XRCC4 [nucleoplasm] (Gallus gallus)

xrcc4 [nucleoplasm] (Dictyostelium discoideum)

xrcc4 [nucleoplasm] (Xenopus tropicalis)

Dmel\CG3448 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of XRCC4 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001304941.1, XP_011541928.1, NP_001304942.1, NP_072044.1, NP_003392.1, NP_071801.1

OpenTargets

ENSG00000152422

HPA

ENSG00000152422-XRCC4

GeneCards

Q13426

Ensembl

ENSP00000282268, ENST00000511817, ENSP00000421491, ENSP00000379344, ENST00000338635, ENSP00000342011, ENST00000396027, ENST00000282268, ENSG00000152422

PRO

Q13426

Pharos - Targets

Q13426

Orphanet

23795

PDB

7LSY, 6ABO, 3II6, 3W03, 1FU1, 5E50, 3SR2, 7NFE, 4XA4, 3Q4F, 7NFC, 5WJ7, 5WLZ, 3MUD, 3RWR, 5CJ0, 1IK9, 5CHX, 7LT3, 5CJ4, 7M3P

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49917 LIG4	1	LIG4 [nucleoplasm] (R-HSA-53791)	0.962	19
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.885	15
UniProt:Q9H9Q4 NHEJ1	1	NHEJ1 [nucleoplasm] (R-HSA-5687247)	0.868	11
UniProt:Q13426 XRCC4	2	monoSUMO1-K210-XRCC4 [nucleoplasm] (R-HSA-4568892) XRCC4 [nucleoplasm] (R-HSA-75911)	0.844	7
UniProt:Q8IW19 APLF			0.797	5
UniProt:Q8IZU0 FAM9B			0.781	7
UniProt:Q7Z2E3 APTX			0.721	4
UniProt:Q0D2I5 IFFO1			0.706	5
UniProt:P12956 XRCC6	5	XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300) XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [nucleoplasm] (R-HSA-58272)	0.656	3
UniProt:Q9H9Q4-1 NHEJ1			0.642	4
UniProt:O00499 BIN1	1	BIN1 [cytosol] (R-HSA-8868265)	0.625	4
UniProt:Q0D2I5-5 IFFO1			0.591	4
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.556	3
UniProt:Q2TB18 ASTE1			0.556	3
UniProt:P43360 MAGA6			0.556	3
UniProt:Q9NVX0 HAUS2	1	HAUS2 [cytosol] (R-HSA-380274)	0.556	3
UniProt:O15499 GSC2			0.556	3
UniProt:Q13426-3 XRCC4			0.556	3
UniProt:Q96SD1 DCLRE1C	3	p-S516,S645-DCLRE1C [nucleoplasm] (R-HSA-5687176) p-S645-DCLRE1C [nucleoplasm] (R-HSA-5686708) DCLRE1C [nucleoplasm] (R-HSA-5686712)	0.462	3