RNA Polymerase III Transcription Initiation From Type 2 Promoter

Stable Identifier
R-HSA-76066
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RNA Polymerase III Transcription Initiation From Type 2 Promoter
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The type 2 promoters can recruit TFIIIC without the help of TFIIIA because TFIIIC binds directly to the A and B boxes. As for the type 1 promoters, this then allows the binding of Brf1-TFIIIB and RNA polymerase III. Importantly, in the yeast system, once Brf1-TFIIIB has been recruited to type 1 or 2 promoters, TFIIIA and/or TFIIIC can be stripped from the DNA with high salt or heparin treatment. Brf1-TFIIIB remains bound to the DNA and is sufficient to direct multiple rounds of transcription .
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Orthologous Events
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RNA Polymerase III Transcription Initiation From Type 2 Promoter (Rattus norvegicus)
RNA Polymerase III Transcription Initiation From Type 2 Promoter (Saccharomyces cerevisiae)
RNA Polymerase III Transcription Initiation From Type 2 Promoter (Schizosaccharomyces pombe)
RNA Polymerase III Transcription Initiation From Type 2 Promoter (Sus scrofa)
RNA Polymerase III Transcription Initiation From Type 2 Promoter (Xenopus tropicalis)
Authored
Hernandez, N  (2003-09-11)
Created
Hernandez, N  (2003-09-11)
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