Coumarin is 7-hydroxylated by CYP2A6

Stable Identifier
R-HSA-76453
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen, smooth endoplasmic reticulum
ReviewStatus
5/5
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Coumarin is 7-hydroxylated by CYP2A6
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The 7-hydroxylation of coumarin is used as an assay of P450 activity in animal and human liver microsomes. CYP2A6 is the major coumarin 7-hydroxylase in human liver.
Literature References
PubMed ID Title Journal Year
15665333 Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6

Kim, KH, Yun, CH, Calcutt, MW, Guengerich, FP

J Biol Chem 2005
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Event Information
Go Biological Process
coumarin metabolic process (0009804)
Catalyst Activity

coumarin 7-hydroxylase activity of Cytochrome P450 (CYP2A3 based) [endoplasmic reticulum membrane]

Physical Entity
Cytochrome P450 (CYP2A3 based) [endoplasmic reticulum membrane] (Homo sapiens)
Activity
coumarin 7-hydroxylase activity (GO:0008389)
Orthologous Events
Coumarin is 7-hydroxylated by CYP2A6 (Bos taurus)
Coumarin is 7-hydroxylated by CYP2A6 (Caenorhabditis elegans)
Coumarin is 7-hydroxylated by CYP2A6 (Canis familiaris)
Coumarin is 7-hydroxylated by CYP2A6 (Danio rerio)
Coumarin is 7-hydroxylated by CYP2A6 (Dictyostelium discoideum)
Coumarin is 7-hydroxylated by CYP2A6 (Drosophila melanogaster)
Coumarin is 7-hydroxylated by CYP2A6 (Mus musculus)
Coumarin is 7-hydroxylated by CYP2A6 (Rattus norvegicus)
Coumarin is 7-hydroxylated by CYP2A6 (Sus scrofa)
Coumarin is 7-hydroxylated by CYP2A6 (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2003-08-05)
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