Addition of nucleotides 10 and 11 on the growing transcript: Third Transition

Stable Identifier
R-HSA-76576
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Formation of phosphodiester bonds nine and ten creates RNA products, which do not dissociate from the RNA pol II initiation complex. The transcription complex has enter the productive elongation phase. TFIIH and ATP-hydrolysis are required for efficient promoter escape. The open region (“transcription bubble”) expands concomitant with the site of RNA-extension. The region upstream from the transcription start site (-9 to -3) collapses to the double-stranded state. TFIIH remains associated to the RNA pol II initiation complex.
Literature References
PubMed ID Title Journal Year
7601352 Recycling of the general transcription factors during RNA polymerase II transcription.

Zawel, L, Kumar, KP, Reinberg, D

Genes Dev 1995
9405375 Three transitions in the RNA polymerase II transcription complex during initiation.

Holstege, FC, Fiedler, U, Timmers, HT

EMBO J 1998
Participants
Input
Output
Participates
as an event of
Catalyst Activity

DNA-directed RNA polymerase activity of RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm]

Physical Entity
RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
Activity
DNA-directed RNA polymerase activity (GO:0003899)
Orthologous Events
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Bos taurus)
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Caenorhabditis elegans)
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Canis familiaris)
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Danio rerio)
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Dictyostelium discoideum)
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Drosophila melanogaster)
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Mus musculus)
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Plasmodium falciparum)
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Rattus norvegicus)
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Saccharomyces cerevisiae)
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Schizosaccharomyces pombe)
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Sus scrofa)
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Xenopus tropicalis)
Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition (Homo sapiens)
Authored
Timmers, HTM  (2003-09-11)
Created
Timmers, HTM  (2003-09-11)
Cite Us!