Reactome | AMP + H2O => IMP + NH4+ (AMPD)

AMP + H2O => IMP + NH4+ (AMPD)

Stable Identifier

R-HSA-76590

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cytosolic AMP deaminase (AMPD) catalyzes the hydrolysis of AMP to yield IMP and ammonia. Three isoforms of AMPD, E, L, and M, have been identified that differ in their expression patterns in the body. All occur as tetramers and all have qualitatively the same catalytic activity, however (Bausch-Jurken et al. 1992; Mahnke-Zizelman et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
1429593	Molecular cloning of AMP deaminase isoform L. Sequence and bacterial expression of human AMPD2 cDNA Bausch-Jurken, MT, Mahnke-Zizelman, DK, Morisaki, T, Sabina, RL	J Biol Chem	1992
9857047	Novel aspects of tetramer assembly and N-terminal domain structure and function are revealed by recombinant expression of human AMP deaminase isoforms Mahnke-Zizelman, DK, Tullson, PC, Sabina, RL	J Biol Chem	1998