Phosphorylation (Ser5) of RNA pol II CTD

Stable Identifier
R-HSA-77071
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation (Ser5) of RNA pol II CTD
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylation of serine 5 residue at the CTD of pol II largest subunit is an important step signaling the end of initiation and escape into processive elongation processes. Cdk7 protein subunit of TFIIH phosphorylates RNA Pol II CTD serine 5 residues on its heptad repeats (Buratowski 2009).

Literature References
PubMed ID Title Journal Year
19941815 Progression through the RNA polymerase II CTD cycle

Buratowski, S

Mol. Cell 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of Pol II transcription complex containing extruded transcript to +30 [nucleoplasm]

Physical Entity
Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation (Ser5) of RNA pol II CTD (Bos taurus)
Phosphorylation (Ser5) of RNA pol II CTD (Caenorhabditis elegans)
Phosphorylation (Ser5) of RNA pol II CTD (Canis familiaris)
Phosphorylation (Ser5) of RNA pol II CTD (Danio rerio)
Phosphorylation (Ser5) of RNA pol II CTD (Dictyostelium discoideum)
Phosphorylation (Ser5) of RNA pol II CTD (Drosophila melanogaster)
Phosphorylation (Ser5) of RNA pol II CTD (Gallus gallus)
Phosphorylation (Ser5) of RNA pol II CTD (Homo sapiens)
Phosphorylation (Ser5) of RNA pol II CTD (Mus musculus)
Phosphorylation (Ser5) of RNA pol II CTD (Plasmodium falciparum)
Phosphorylation (Ser5) of RNA pol II CTD (Rattus norvegicus)
Phosphorylation (Ser5) of RNA pol II CTD (Saccharomyces cerevisiae)
Phosphorylation (Ser5) of RNA pol II CTD (Schizosaccharomyces pombe)
Phosphorylation (Ser5) of RNA pol II CTD (Sus scrofa)
Phosphorylation (Ser5) of RNA pol II CTD (Xenopus tropicalis)
Authored
Buratowski, S  (2003-10-15)
Created
Buratowski, S  (2003-10-15)
Cite Us!