Methylation of GMP-cap by RNA Methyltransferase

Stable Identifier
R-HSA-77090
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Methylation of GMP-cap by RNA Methyltransferase
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In the final step of the capping reaction, the methyltransferase takes a methyl group from S-adenosyl-methionine to the N7 position of the cap guanine. N7G-methyltransferase (MT) mediated reaction can be represented as:
GpppN(pN)n + S-adenosylmethionine (Adomet) ->m7GpppN(pN)n + S-adenosylhomocysteine (Adohcy).

Literature References
PubMed ID Title Journal Year
9790902 Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase.

Shibagaki, Y, Niikura, Y, Tsukamoto, T, Mizumoto, K

Biochem Biophys Res Commun 1998
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Catalyst Activity

mRNA (guanine-N7-)-methyltransferase activity of Capping complex (with freed 5'- GMP) [nucleoplasm]

Physical Entity
Capping complex (with freed 5'- GMP) [nucleoplasm] (Homo sapiens)
Activity
mRNA (guanine-N7-)-methyltransferase activity (GO:0004482)
Orthologous Events
Methylation of GMP-cap by RNA Methyltransferase (Bos taurus)
Methylation of GMP-cap by RNA Methyltransferase (Caenorhabditis elegans)
Methylation of GMP-cap by RNA Methyltransferase (Canis familiaris)
Methylation of GMP-cap by RNA Methyltransferase (Danio rerio)
Methylation of GMP-cap by RNA Methyltransferase (Dictyostelium discoideum)
Methylation of GMP-cap by RNA Methyltransferase (Drosophila melanogaster)
Methylation of GMP-cap by RNA Methyltransferase (Mus musculus)
Methylation of GMP-cap by RNA Methyltransferase (Rattus norvegicus)
Methylation of GMP-cap by RNA Methyltransferase (Saccharomyces cerevisiae)
Methylation of GMP-cap by RNA Methyltransferase (Schizosaccharomyces pombe)
Methylation of GMP-cap by RNA Methyltransferase (Sus scrofa)
Methylation of GMP-cap by RNA Methyltransferase (Xenopus tropicalis)
Authored
Buratowski, S  (2003-10-15)
Created
Buratowski, S  (2003-10-15)
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