Reactome | HADHB [mitochondrial inner membrane]

HADHB [mitochondrial inner membrane]

Stable Identifier

R-HSA-77266

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Trifunctional enzyme beta subunit, Trifunctional enzyme beta subunit, mitochondrial precursor, TP-beta, 3-ketoacyl-CoA thiolase , Acetyl-CoA acyltransferase, Beta-ketothiolase

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P55084 HADHB

Gene Names

HADHB, MSTP029

Chain

transit peptide:1-33, chain:34-474

Reference Genes

BioGPS Gene:3032 HADHB

COSMIC (genes):HADHB HADHB

CTD Gene:3032 HADHB

dbSNP Gene:3032 HADHB

ENSEMBL:ENSG00000138029 HADHB

ENSEMBL_homo_sapiens_GENE:ENSG00000138029.14 HADHB

HGNC:4803 HADHB

KEGG Gene (Homo sapiens):3032 HADHB

Monarch:3032 HADHB

NCBI Gene:3032 HADHB

OMIM:143450 HADHB

UCSC:P55084 HADHB

Reference Transcript

Other Identifiers

11725038_s_at

11745163_s_at

11745164_x_at

11747745_a_at

11747746_x_at

16877860

201007_PM_at

201007_at

2473736

2473740

2473741

2473745

2473748

2473749

2473751

2473754

2473756

2473758

2473760

2473763

2473764

2473765

2473766

2473767

2473768

2473769

2473773

2473774

2473775

3032

39741_at

3998182

74819_at

8040639

D16481_at

GE80900

GO:0003723

GO:0003824

GO:0003857

GO:0003985

GO:0003988

GO:0004300

GO:0005515

GO:0005739

GO:0005740

GO:0005741

GO:0005743

GO:0005783

GO:0006629

GO:0006631

GO:0006635

GO:0010467

GO:0016020

GO:0016491

GO:0016507

GO:0016740

GO:0016746

GO:0016747

GO:0016829

GO:0042645

GO:0043226

GO:0050633

GO:0071222

GO:0106222

HMNXSV003020155

ILMN_2197846

PH_hs_0029551

TC02000149.hg

g4504326_3p_at

Participates

as a component of

Inferred To

HADHB [mitochondrial inner membrane] (Bos taurus)

HADHB [mitochondrial inner membrane] (Caenorhabditis elegans)

HADHB [mitochondrial inner membrane] (Canis familiaris)

HADHB [mitochondrial inner membrane] (Gallus gallus)

HADHB [mitochondrial inner membrane] (Sus scrofa)

Hadhb [mitochondrial inner membrane] (Mus musculus)

Hadhb [mitochondrial inner membrane] (Rattus norvegicus)

Mtpbeta [mitochondrial inner membrane] (Drosophila melanogaster)

hadhb [mitochondrial inner membrane] (Danio rerio)

hadhb [mitochondrial inner membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_000174.1, NP_001268441.1, NP_001268442.1, XP_011531105.1

OpenTargets

ENSG00000138029

GeneCards

P55084

HPA

ENSG00000138029-HADHB

Ensembl

ENST00000545822, ENST00000317799, ENSP00000442665, ENSG00000138029, ENSP00000325136

PRO

P55084

Pharos - Targets

P55084

Orphanet

16834

HMDB Protein

HMDBP00048

PDB

6DV2, 5ZRV, 5ZQZ

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.643	3
UniProt:O15530 PDPK1	2	PDPK1 [cytosol] (R-HSA-202210) PDPK1 [plasma membrane] (R-HSA-61459)	0.527	3
UniProt:Q05513 PRKCZ	5	p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) PRKCZ [cytosol] (R-HSA-58218) PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)	0.527	2
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) p-Y179,Y191-SDC2 [plasma membrane] (R-HSA-4093306) SDC2 [lysosomal lumen] (R-HSA-2090083) HS(6)-SDC2 [lysosomal lumen] (R-HSA-2090064) HS(6)-SDC2 [Golgi lumen] (R-HSA-2076588) HS(5)-SDC2 [Golgi lumen] (R-HSA-2076320) Heparan-SDC2 [Golgi lumen] (R-HSA-2076608) Heparan(1)-SDC2 [Golgi lumen] (R-HSA-2076536) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643)	0.527	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	11
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	4

Cite Us!