Cleavage and polyadenylation of Intronless Pre-mRNA

Stable Identifier
R-HSA-77593
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Cleavage and polyadenylation of Intronless Pre-mRNA
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The nuclear poly(A) binding protein (PABPN1), which binds the growing poly(A) tails once it has reached a length of about ten nucleotides. Stimulation of poly(A) polymerase by both CPSF and PABPN1 is synergistic and results in processive elongation of the RNA (the polymerase adds AMP residues without dissociating from the RNA). The processive reaction is terminated when the tail has reached a length of about 250 nucleotides.
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Orthologous Events
Cleavage and polyadenylation of Intronless Pre-mRNA (Bos taurus)
Cleavage and polyadenylation of Intronless Pre-mRNA (Caenorhabditis elegans)
Cleavage and polyadenylation of Intronless Pre-mRNA (Drosophila melanogaster)
Cleavage and polyadenylation of Intronless Pre-mRNA (Gallus gallus)
Cleavage and polyadenylation of Intronless Pre-mRNA (Mus musculus)
Cleavage and polyadenylation of Intronless Pre-mRNA (Rattus norvegicus)
Cleavage and polyadenylation of Intronless Pre-mRNA (Sus scrofa)
Authored
Wahle, E  (2003-06-05)
Created
Wahle, E  (2003-06-05)
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