Glucagon:GCGR mediates GTP-GDP exchange

Stable Identifier
R-HSA-825631
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Glucagon:GCGR mediates GTP-GDP exchange
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The G(s)alpha G-beta G-gamma complex bound to glucagon, in the plasma membrane, releases a molecule of bound GDP, binds a molecule of GTP, and dissociates to yield a G(s)alpha:GTP complex and a G-beta:G-gamma dimer (Siu et al. 2013).
Literature References
PubMed ID Title Journal Year
23863937 Structure of the human glucagon class B G-protein-coupled receptor

de Graaf, C, Xu, Q, Lau, J, Cherezov, V, Zhou, C, Wang, MW, Wacker, D, Siu, FY, Yang, D, He, M, Katritch, V, Joseph, JS, Liu, W, Han, GW, Stevens, RC, Zhang, Z

Nature 2013
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Catalyst Activity

guanyl-nucleotide exchange factor activity of GCGR:GCG(53-81) [plasma membrane]

Physical Entity
GCGR:GCG(53-81) [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Authored
Gopinathrao, G  (2005-08-12)
Reviewed
D'Eustachio, P  (2010-05-26)
Created
D'Eustachio, P  (2010-05-26)
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