Reactome | GTF3C3 [nucleoplasm]

GTF3C3 [nucleoplasm]

Stable Identifier

R-HSA-83691

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

TFIIC102

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y5Q9 GTF3C3

Gene Names

GTF3C3

Chain

initiator methionine:, chain:2-886

Reference Genes

BioGPS Gene:9330 GTF3C3

COSMIC (genes):GTF3C3 GTF3C3

CTD Gene:9330 GTF3C3

dbSNP Gene:9330 GTF3C3

ENSEMBL:ENSG00000119041 GTF3C3

ENSEMBL_homo_sapiens_GENE:ENSG00000119041.11 GTF3C3

HGNC:4666 GTF3C3

KEGG Gene (Homo sapiens):9330 GTF3C3

Monarch:9330 GTF3C3

NCBI Gene:9330 GTF3C3

OMIM:604888 GTF3C3

UCSC:Q9Y5Q9 GTF3C3

Reference Transcript

Other Identifiers

11743763_at

11749438_a_at

11759515_at

11759516_s_at

11761590_at

1555439_PM_at

1555439_at

16906800

218343_PM_s_at

218343_s_at

222604_PM_at

222604_at

2593349

2593351

2593353

2593354

2593355

2593356

2593357

2593358

2593360

2593361

2593362

2593365

2593367

2593368

2593370

2593372

2593373

2593376

2593377

2593378

2593379

2593380

2593381

2593382

2593383

2593384

2593385

2593386

2593387

2593392

2593393

2593394

55602_at

77663_at

8057933

9330

A_23_P429535

A_23_P56437

A_24_P50818

GE58453

GE616278

GO:0000127

GO:0000995

GO:0001650

GO:0003677

GO:0005515

GO:0005634

GO:0005635

GO:0005654

GO:0005730

GO:0006351

GO:0006383

GO:0006399

GO:0031965

GO:0042791

GO:0042797

GO:0043226

GO:0140223

HMNXSV003022137

HMNXSV003053884

Hs.90847.0.S2_3p_at

Hs2.90847.2.S1_3p_at

ILMN_1789508

PH_hs_0026897

TC02002642.hg

g6912397_3p_a_at

Participates

as a component of

TFIIIC [nucleoplasm] (Homo sapiens)

Inferred To

gtf3c3 [nucleoplasm] (Xenopus tropicalis)

sfc4 [nucleoplasm] (Schizosaccharomyces pombe)

GTF3C3 [nucleoplasm] (Bos taurus)

GTF3C3 [nucleoplasm] (Canis familiaris)

GTF3C3 [nucleoplasm] (Gallus gallus)

GTF3C3 [nucleoplasm] (Sus scrofa)

TFC4 [nucleoplasm] (Saccharomyces cerevisiae)

TFIIIC3 [nucleoplasm] (Dictyostelium discoideum)

Dmel\CG8950 [nucleoplasm] (Drosophila melanogaster)

Gtf3c3 [nucleoplasm] (Mus musculus)

Gtf3c3 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001193703.1, NP_036218.1

OpenTargets

ENSG00000119041

GeneCards

Q9Y5Q9

HPA

ENSG00000119041-GTF3C3

Ensembl

ENSP00000386465, ENSG00000119041, ENST00000263956, ENST00000409364, ENSP00000263956

PRO

Q9Y5Q9

Pharos - Targets

Q9Y5Q9

PDB

8CLK

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.75	5
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	12
UniProt:Q14693 LPIN1	3	p-S106-LPIN1 [nucleoplasm] (R-HSA-4419936) LPIN1 [nuclear envelope] (R-HSA-4419927) LPIN1 [endoplasmic reticulum membrane] (R-HSA-549157)	0.556	3
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.556	3
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.556	3
UniProt:P60896 SEM1	2	SEM1 [nucleoplasm] (R-HSA-8866665) SEM1 [cytosol] (R-HSA-8866674)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.527	2
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.527	2
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) p-Y179,Y191-SDC2 [plasma membrane] (R-HSA-4093306) SDC2 [lysosomal lumen] (R-HSA-2090083) HS(6)-SDC2 [lysosomal lumen] (R-HSA-2090064) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(6)-SDC2 [Golgi lumen] (R-HSA-2076588) HS(5)-SDC2 [Golgi lumen] (R-HSA-2076320) Heparan-SDC2 [Golgi lumen] (R-HSA-2076608) Heparan(1)-SDC2 [Golgi lumen] (R-HSA-2076536) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) SDC2 [Golgi lumen] (R-HSA-2054101) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643)	0.527	2
UniProt:Q96GD4 AURKB	3	polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [nucleoplasm] (R-HSA-4655360) AURKB [cytosol] (R-HSA-174231)	0.483	2