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POLR2L [nucleoplasm]
Stable Identifier
R-HSA-83715
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
HsRPABC5, DNA-directed RNA polymerase II 7.6 kDa polypeptide (EC 2.7.7.6) (RPB10) (RPB7.6), DNA-directed RNA polymerase II 7.6 kDa polypeptide , RPB10, RPB7.6, RPABC5
Locations in the PathwayBrowser for interactor UniProt:Q9NQG5 RPRD1B
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase I Transcription (Homo sapiens)
RNA Polymerase I Promoter Clearance (Homo sapiens)
RNA Polymerase I Transcription Initiation (Homo sapiens)
Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)
POLR2L [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62875 POLR2L
Gene Names
POLR2L
Chain
chain:1-67
Reference Genes
BioGPS Gene:5441 POLR2L
COSMIC (genes):POLR2L POLR2L
CTD Gene:5441 POLR2L
dbSNP Gene:5441 POLR2L
ENSEMBL:ENSG00000177700 POLR2L
ENSEMBL_homo_sapiens_GENE:ENSG00000177700.6 POLR2L
HGNC:9199 POLR2L
KEGG Gene (Homo sapiens):5441 POLR2L
Monarch:5441 POLR2L
NCBI Gene:5441 POLR2L
OMIM:601189 POLR2L
UCSC:P62875 POLR2L
Reference Transcript
RefSeq:NM_021128.4 POLR2L
Other Identifiers
11716442_a_at
11753875_a_at
11753876_x_at
16734154
202586_PM_at
202586_at
211730_PM_s_at
211730_s_at
3358494
3358495
3358498
3358499
3358500
35841_at
503_at
5441
78238_at
7945573
A_23_P33015
GE79031
GO:0000428
GO:0001054
GO:0001055
GO:0001056
GO:0003677
GO:0003824
GO:0003899
GO:0005515
GO:0005634
GO:0005654
GO:0005665
GO:0005666
GO:0005730
GO:0005736
GO:0005829
GO:0006351
GO:0006355
GO:0006356
GO:0006360
GO:0006366
GO:0006399
GO:0008270
GO:0016740
GO:0042797
GO:0043226
GO:0046872
GO:0140098
HMNXSV003013515
Hs.71618.0.S2_3p_at
ILMN_1670037
TC11001251.hg
U37690_at
g13543491_3p_s_at
Participates
as a component of
RNA Polymerase III Holoenzyme [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (p-Ser2,7 CTD) [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (p-Ser5,7 CTD) [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Homo sapiens)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex phosphorylated by CDK12 [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (generic) [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
as an input of
Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)
Other forms of this molecule
POLR2L [cytosol]
Inferred To
polr2l [nucleoplasm]
(Danio rerio)
polr2l [nucleoplasm]
(Xenopus tropicalis)
AC109542.1 [nucleoplasm]
(Rattus norvegicus)
POLR2L [nucleoplasm]
(Bos taurus)
POLR2L [nucleoplasm]
(Caenorhabditis elegans)
POLR2L [nucleoplasm]
(Canis familiaris)
POLR2L [nucleoplasm]
(Dictyostelium discoideum)
POLR2L [nucleoplasm]
(Drosophila melanogaster)
POLR2L [nucleoplasm]
(Gallus gallus)
POLR2L [nucleoplasm]
(Mus musculus)
POLR2L [nucleoplasm]
(Plasmodium falciparum)
POLR2L [nucleoplasm]
(Saccharomyces cerevisiae)
POLR2L [nucleoplasm]
(Schizosaccharomyces pombe)
POLR2L [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_066951.1
OpenTargets
ENSG00000177700
HPA
ENSG00000177700-POLR2L
GeneCards
P62875
Ensembl
ENSP00000324124
,
ENSP00000432807
,
ENSG00000177700
,
ENST00000534030
,
ENST00000322028
PRO
P62875
Pharos - Targets
P62875
HMDB Protein
HMDBP11915
PDB
5IYB
,
7AST
,
8A43
,
5IYC
,
7FJI
,
7FJJ
,
7VBC
,
7AEA
,
5IYA
,
7VBA
,
8IUH
,
5IY8
,
7DU2
,
7VBB
,
5IY9
,
6XRE
,
5IY6
,
6O9L
,
5IY7
,
8IUE
,
7AE3
,
7AE1
,
7OBA
,
7OBB
,
7A6H
,
8ITY
,
7LBM
,
7DN3
,
7D59
,
7OB9
,
7D58
,
5IYD
,
6DRD
Interactors (44)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19388 POLR2E
2
POLR2E [nucleoplasm]
(R-HSA-83713)
POLR2E [cytosol]
(R-HSA-1964438)
0.867
9
UniProt:O15514 POLR2D
1
POLR2D [nucleoplasm]
(R-HSA-63508)
0.738
5
UniProt:Q9BWH6 RPAP1
0.666
5
UniProt:P38432 COIL
0.556
3
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.556
3
UniProt:Q8N9N5 BANP
1
BANP [nucleoplasm]
(R-HSA-3221973)
0.556
3
UniProt:P60900 PSMA6
2
PSMA6 [nucleoplasm]
(R-HSA-174314)
PSMA6 [cytosol]
(R-HSA-68734)
0.556
3
UniProt:Q13625-3 TP53BP2
0.556
3
UniProt:Q96R06 SPAG5
0.556
3
UniProt:Q96JM7 LMBL3
0.556
3
UniProt:Q9NTX9 F217B
0.556
3
UniProt:Q04864-2 REL
0.556
3
UniProt:O95994 AGR2
0.556
3
UniProt:Q9NVV9 THAP1
0.556
3
UniProt:O43829 ZBT14
0.556
3
UniProt:Q96RE7 NACC1
0.556
3
UniProt:Q8IXK0 PHC2
1
PHC2 [nucleoplasm]
(R-HSA-389112)
0.556
3
UniProt:Q15645 PCH2
0.556
3
UniProt:P62487 POLR2G
1
POLR2G [nucleoplasm]
(R-HSA-63517)
0.527
3
UniProt:Q9NW08 POLR3B
2
POLR3B [cytosol]
(R-HSA-1964435)
POLR3B [nucleoplasm]
(R-HSA-83702)
0.527
3
UniProt:Q9NQG5 RPRD1B
1
RPRD1B [nucleoplasm]
(R-HSA-6814894)
0.527
3
UniProt:Q96P16 RPRD1A
1
RPRD1A [nucleoplasm]
(R-HSA-6814899)
0.527
3
UniProt:Q9NWS0 PIHD1
0.527
2
UniProt:O95402 MED26
1
MED26 [nucleoplasm]
(R-HSA-556783)
0.527
3
UniProt:P30876 POLR2B
1
POLR2B [nucleoplasm]
(R-HSA-63504)
0.527
3
UniProt:Q9BT43 POLR3GL
2
POLR3GL [nucleoplasm]
(R-HSA-1964458)
POLR3GL [cytosol]
(R-HSA-1964463)
0.527
3
UniProt:P52435 POLR2J
1
POLR2J [nucleoplasm]
(R-HSA-63531)
0.527
4
UniProt:P19387 POLR2C
1
POLR2C [nucleoplasm]
(R-HSA-63506)
0.527
3
UniProt:Q9NVU0 POLR3E
2
POLR3E [nucleoplasm]
(R-HSA-83706)
POLR3E [cytosol]
(R-HSA-1964451)
0.527
3
UniProt:P61218 POLR2F
2
POLR2F [nucleoplasm]
(R-HSA-83714)
POLR2F [cytosol]
(R-HSA-1964441)
0.527
4
UniProt:P05423 POLR3D
2
POLR3D [cytosol]
(R-HSA-1964429)
POLR3D [nucleoplasm]
(R-HSA-83704)
0.527
3
UniProt:A6NED2 RCCD1
2
3OHR141-RCCD1 [cytosol]
(R-HSA-9629871)
RCCD1 [cytosol]
(R-HSA-9629873)
0.527
3
UniProt:Q9H9Y4 GPN2
0.527
3
UniProt:O00267 SUPT5H
1
p-SUPT5H [nucleoplasm]
(R-HSA-3009372)
0.527
2
UniProt:Q9GZS1 POLR1E
1
POLR1E [nucleoplasm]
(R-HSA-5419294)
0.527
3
UniProt:O15160 POLR1C
2
POLR1C [nucleoplasm]
(R-HSA-63498)
POLR1C [cytosol]
(R-HSA-1964454)
0.527
3
UniProt:Q9H9Y6 POLR1B
1
POLR1B [nucleoplasm]
(R-HSA-63496)
0.527
3
UniProt:Q9Y535 POLR3H
2
POLR3H [nucleoplasm]
(R-HSA-83710)
POLR3H [cytosol]
(R-HSA-1964440)
0.527
3
UniProt:O14802 POLR3A
2
POLR3A [cytosol]
(R-HSA-1964433)
POLR3A [nucleoplasm]
(R-HSA-83700)
0.527
3
UniProt:A0JLT2 MED19
1
MED19 [nucleoplasm]
(R-HSA-556819)
0.527
2
UniProt:P0DPB6 RPAC2
0.527
2
UniProt:Q9H1D9 POLR3F
2
POLR3F [cytosol]
(R-HSA-1964434)
POLR3F [nucleoplasm]
(R-HSA-83708)
0.527
3
UniProt:P52434 POLR2H
2
POLR2H [nucleoplasm]
(R-HSA-63523)
POLR2H [cytosol]
(R-HSA-1964450)
0.527
2
UniProt:O95602 POLR1A
1
POLR1A [nucleoplasm]
(R-HSA-63494)
0.527
3
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