Reactome | TBP [nucleoplasm]

TBP [nucleoplasm]

Stable Identifier

R-HSA-83718

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

TATA box binding protein (Transcription initiation factor TFIID) (TATA-box factor) (TATA sequence-binding protein) (TBP), TATA-box binding protein, TATA-box factor, TATA binding factor, TATA sequence-binding protein, Transcription initiation factor TFIID TBP subunit

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Nuclear Receptors (Homo sapiens)
  - ESR-mediated signaling (Homo sapiens)
    - Estrogen-dependent gene expression (Homo sapiens)
      - CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Homo sapiens)
        
        CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP [nucleoplasm] (Homo sapiens)
      - Estrogen-responsive TFF1 gene expression (Homo sapiens)
        
        ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1 [nucleoplasm] (Homo sapiens)
        
        CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP [nucleoplasm] (Homo sapiens)
      - Histone acetyltransferases are recruited to the TFF1 gene (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1 [nucleoplasm] (Homo sapiens)
        
        CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1 [nucleoplasm] (Homo sapiens)
        
        CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP [nucleoplasm] (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP [nucleoplasm] (Homo sapiens)
      - PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Homo sapiens)
        
        ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP [nucleoplasm] (Homo sapiens)
      - TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter (Homo sapiens)
        
        TBP [nucleoplasm] (Homo sapiens)
        
        TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
        
        TBP [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P20226 TBP

Gene Names

TBP, GTF2D1, TF2D, TFIID

Chain

chain:1-339

Reference Genes

BioGPS Gene:6908 TBP

COSMIC (genes):TBP TBP

CTD Gene:6908 TBP

dbSNP Gene:6908 TBP

ENSEMBL:ENSG00000112592 TBP

ENSEMBL_homo_sapiens_GENE:ENSG00000112592.15 TBP

HGNC:11588 TBP

KEGG Gene (Homo sapiens):6908 TBP

Monarch:6908 TBP

NCBI Gene:6908 TBP

OMIM:600075 TBP

UCSC:P20226 TBP

Reference Transcript

Other Identifiers

11735454_s_at

11749863_a_at

17014929

203135_PM_at

203135_at

2937985

2937990

2937991

2937992

2937993

2937994

2937995

2937997

2937998

2938002

2938003

2938005

2938007

2938008

2938009

41441_at

6908

8123507

A_23_P19313

GE57977

GO:0000785

GO:0000791

GO:0000976

GO:0000978

GO:0000979

GO:0000995

GO:0001046

GO:0001091

GO:0001093

GO:0001673

GO:0001674

GO:0001939

GO:0001940

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005668

GO:0005669

GO:0005672

GO:0005694

GO:0005730

GO:0005737

GO:0006351

GO:0006352

GO:0006355

GO:0006366

GO:0006367

GO:0006383

GO:0007283

GO:0016071

GO:0016251

GO:0017162

GO:0019899

GO:0022414

GO:0032991

GO:0042789

GO:0043226

GO:0045120

GO:0045893

GO:0051123

GO:0060261

GO:0061629

GO:0065003

GO:0140223

GO:0140297

HMNXSV003005594

ILMN_1697117

PH_hs_0000144

TC06001201.hg

TC06003242.hg

X54993_s_at

g4507378_3p_at

Participates

as a component of

as an input of

Inferred To

Ghost homologue of TBP [nucleoplasm] (Sus scrofa)

SPT15 [nucleoplasm] (Saccharomyces cerevisiae)

tbp1 [nucleoplasm] (Schizosaccharomyces pombe)

tbp [nucleoplasm] (Danio rerio)

tbp [nucleoplasm] (Xenopus tropicalis)

Trf [nucleoplasm] (Drosophila melanogaster)

Homologues of TBP [nucleoplasm] (Drosophila melanogaster)

TBP [nucleoplasm] (Bos taurus)

TBP [nucleoplasm] (Canis familiaris)

TBP [nucleoplasm] (Gallus gallus)

tbpA [nucleoplasm] (Dictyostelium discoideum)

Tbp [nucleoplasm] (Drosophila melanogaster)

Tbp [nucleoplasm] (Mus musculus)

Tbp [nucleoplasm] (Rattus norvegicus)

tbp-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001165556.1, NP_003185.1

OpenTargets

ENSG00000112592

HPA

ENSG00000112592-TBP

GeneCards

P20226

Ensembl

ENSG00000112592, ENSP00000230354, ENST00000230354, ENSP00000442132, ENST00000392092, ENSP00000375942, ENST00000540980

PRO

P20226

Pharos - Targets

P20226

Orphanet

15583

PDB

5IY9, 6MZM, 1TGH, 5IY7, 5IY8, 7NVZ, 7ENC, 7ENA, 7NW0, 1C9B, 7NVY, 7NVU, 5IY6, 7EGA, 8ITY, 7ZWD, 4ROE, 4ROD, 7EGJ, 7ZWC, 7NVT, 5IYB, 7ZXE, 5IYA, 7EGI, 7EG9, 4ROC, 7EG7, 6O9L, 7EGF, 8GXQ, 7EGE, 7ZX8, 6MZL, 7ZX7, 7EGD, 7EGC, 6MZD, 8IUH, 8BVW, 7EGB, 8IUE, 5IYC, 5IYD, 7NVS, 7LBM, 7NVR, 8BZ1, 5N9G, 7EG8, 8BYQ, 7EDX, 5FUR, 1JFI, 1CDW, 1NVP, 8GXS

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21675 TAF1	1	TAF1 [nucleoplasm] (R-HSA-65539)	0.86	10
UniProt:P03070 LT			0.815	8
UniProt:Q12962 TAF10	1	TAF10 [nucleoplasm] (R-HSA-65551)	0.725	5
UniProt:Q15542 TAF5	1	TAF5 [nucleoplasm] (R-HSA-65543)	0.725	4
UniProt:Q53T94 TAF1B	2	TAF1B [nucleoplasm] (R-HSA-73691) Ac-TAF1B [nucleoplasm] (R-HSA-5138530)	0.688	4
UniProt:Q16514 TAF12	1	TAF12 [nucleoplasm] (R-HSA-65555)	0.669	3
UniProt:Q15572 TAF1C	1	TAF1C [nucleoplasm] (R-HSA-73687)	0.656	3
UniProt:O00268 TAF4	1	TAF4 [nucleoplasm] (R-HSA-65541)	0.643	3
UniProt:Q01105 SET	1	SET [nucleoplasm] (R-HSA-451201)	0.632	4
UniProt:Q16236 NFE2L2	13	p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-NFE2L2 [cytosol] (R-HSA-9758077) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109)	0.625	5
UniProt:P52657 GTF2A2	1	GTF2A2 [nucleoplasm] (R-HSA-65533)	0.623	2
UniProt:Q05906 ICP27			0.611	4
UniProt:P03120 VE2			0.592	2
UniProt:Q00403 GTF2B	1	GTF2B [nucleoplasm] (R-HSA-65888)	0.589	2
UniProt:P52655 GTF2A1	2	GTF2A1(275-376) [nucleoplasm] (R-HSA-109768) GTF2A1(1-274) [nucleoplasm] (R-HSA-109767)	0.564	2
UniProt:Q15573 TAF1A	1	TAF1A [nucleoplasm] (R-HSA-73689)	0.564	2
UniProt:Q9H5J8 TAF1D	1	TAF1D [nucleoplasm] (R-HSA-5138533)	0.564	2
UniProt:L8B1Q7 L8B1Q7			0.558	3
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q92994 BRF1	1	BRF1 [nucleoplasm] (R-HSA-65894)	0.547	2
UniProt:P87662 P87662			0.544	2
UniProt:Q6JGG5 Q6JGG5			0.544	3
UniProt:P35226 BMI1	3	BMI1 [nucleoplasm] (R-HSA-389121) p-S-BMI1 [nucleoplasm] (R-HSA-3229116) monoSUMO1-K88-BMI1 [nucleoplasm] (R-HSA-4551729)	0.527	2
UniProt:P20265 POU3F2	1	POU3F2 [nucleoplasm] (R-HSA-9613754)	0.527	2
UniProt:P49848 TAF6	1	TAF6 [nucleoplasm] (R-HSA-65545)	0.527	2
UniProt:Q15545 TAF7	1	TAF7 [nucleoplasm] (R-HSA-212347)	0.527	2
UniProt:P18111 CDX1			0.524	5
UniProt:O60869-1 EDF1			0.499	2
UniProt:Q5HZG4	1	Taf3 [nucleoplasm] (R-MMU-212446)	0.462	2

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