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GAST(76-92) [extracellular region]
Stable Identifier
R-HSA-870266
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Gastrin, Gastrin-17, Gastrin component recommendedName: Gastrin-71, GAST, GAST_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)
Gastrin binds to CCK-B receptor (Homo sapiens)
GAST(76-92) [extracellular region] (Homo sapiens)
Gastrin:CCKBR [plasma membrane] (Homo sapiens)
GAST(76-92) [extracellular region] (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Gastrin:CCKBR [plasma membrane] (Homo sapiens)
GAST(76-92) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Gastrin:CCKBR [plasma membrane] (Homo sapiens)
GAST(76-92) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Gastrin:CCKBR [plasma membrane] (Homo sapiens)
GAST(76-92) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Gastrin:CCKBR [plasma membrane] (Homo sapiens)
GAST(76-92) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Gastrin:CCKBR [plasma membrane] (Homo sapiens)
GAST(76-92) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
GAST(76-92) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01350 GAST
Gene Names
GAST, GAS
Chain
signal peptide:1-21, peptide:22-92, peptide:41-92, peptide:59-92, peptide:76-92, peptide:79-92, peptide:87-92, propeptide:96-101
Reference Genes
BioGPS Gene:2520 GAST
COSMIC (genes):GAST GAST
CTD Gene:2520 GAST
dbSNP Gene:2520 GAST
ENSEMBL:ENSG00000184502 GAST
HGNC:4164 GAST
KEGG:hsa:2520 GAST
Monarch:2520 GAST
NCBI Gene:2520 GAST
OMIM:137250 GAST
UCSC:P01350 GAST
Reference Transcript
RefSeq:NM_000805.4 GAST
Other Identifiers
11730167_at
16834189
208138_PM_at
208138_at
2520
34552_at
3721427
3721428
3721429
3721430
8007148
A_23_P159191
GE481074
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0007165
GO:0007186
GO:0032094
GO:0048018
GO:0098772
HMNXSV003029462
ILMN_1712721
M15958_at
PH_hs_0000348
TC17000515.hg
g6005999_3p_at
Participates
as an input of
Gastrin binds to CCK-B receptor (Homo sapiens)
as a member of
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
as a component of
Gastrin:CCKBR [plasma membrane] (Homo sapiens)
Inferred To
GAST [extracellular region]
(Bos taurus)
GAST [extracellular region]
(Canis familiaris)
GAST(76-92) [extracellular region]
(Sus scrofa)
Gast [extracellular region]
(Mus musculus)
Gast [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_000796.1
OpenTargets
ENSG00000184502
ENSEMBL
ENST00000329402
,
ENSP00000331358
HPA
ENSG00000184502-GAST
PRO
P01350
Pharos - Targets
P01350
GlyGen
P01350
PDB
7F8V
,
7F8W
,
7XOW
,
5WRJ
Interactors (30)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02787 TF
6
TF [endoplasmic reticulum lumen]
(R-HSA-8956763)
p-TF [endoplasmic reticulum lumen]
(R-HSA-8957001)
apoTF [endosome membrane]
(R-HSA-917974)
apoTF [extracellular region]
(R-HSA-350754)
TF [secretory granule lumen]
(R-HSA-350704)
apoTF [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869140)
0.618
5
UniProt:Q14973 SLC10A1
1
SLC10A1 [plasma membrane]
(R-HSA-194116)
0.556
3
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
5
UniProt:Q8N5K1 CISD2
0.556
3
UniProt:Q15546 PAQRB
0.556
3
UniProt:Q12797-6 ASPH
0.556
3
UniProt:Q13520 AQP6
1
AQP6 [transport vesicle membrane]
(R-HSA-431741)
0.556
3
UniProt:Q9BXK5 B2L13
0.556
3
UniProt:P00387 CYB5R3
3
CYB5R3(27-301) [azurophil granule lumen]
(R-HSA-6799217)
CYB5R3(27-301) [extracellular region]
(R-HSA-6806205)
MyrG-CYB5R3(2-301) [mitochondrial outer membrane]
(R-HSA-198771)
0.556
3
UniProt:Q5JX71 F209A
0.556
3
UniProt:Q4KMG9 TM52B
0.556
3
UniProt:O76011 KRT34
1
KRT34 [cytosol]
(R-HSA-6809608)
0.556
3
UniProt:Q9Y282 ERGI3
0.556
3
UniProt:Q8NBJ4 GOLM1
2
p-GOLM1 [endoplasmic reticulum lumen]
(R-HSA-8956938)
GOLM1 [endoplasmic reticulum lumen]
(R-HSA-8956710)
0.556
3
UniProt:Q13113 PDZ1I
0.556
3
UniProt:O43315 AQP9
1
AQP9 [plasma membrane]
(R-HSA-431761)
0.556
3
UniProt:Q8TDT2 GP152
0.556
3
UniProt:Q6ZUX7 LHFPL2
2
LHFPL2 [plasma membrane]
(R-HSA-8862949)
LHFPL2 [platelet alpha granule membrane]
(R-HSA-8862969)
0.556
3
UniProt:P15941-11 MUC1
0.556
3
UniProt:P60201-2 PLP1
0.556
3
UniProt:P43628 KIR2DL3
1
KIR2DL3 [plasma membrane]
(R-HSA-3006532)
0.556
3
UniProt:Q9NYZ3 GTSE1
4
GTSE1 [cytosol]
(R-HSA-8852264)
p-S435-GTSE1 [cytosol]
(R-HSA-8852316)
p-S435-GTSE1 [nucleoplasm]
(R-HSA-8852332)
p-T513,T526-GTSE1 [cytosol]
(R-HSA-8852308)
0.527
2
UniProt:O60361 NME2P1
1
NME2P1 [cytosol]
(R-HSA-6806876)
0.527
2
UniProt:O43149 ZZEF1
0.527
3
UniProt:Q9NRJ7 PCDBG
0.527
2
UniProt:Q8WTP9 XAGE3
0.527
2
UniProt:O75815 BCAR3
0.527
2
UniProt:Q7Z7L7 ZER1
0.527
3
UniProt:Q5T447 HECTD3
1
HECTD3 [cytosol]
(R-HSA-975991)
0.527
2
UniProt:O95260 ATE1
0.527
3
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