Reactome | GAST(76-92) [extracellular region]

GAST(76-92) [extracellular region]

Stable Identifier

R-HSA-870266

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Gastrin, Gastrin-17, Gastrin component recommendedName: Gastrin-71, GAST, GAST_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P01350 GAST

Gene Names

GAST, GAS

Chain

signal peptide:1-21, peptide:22-92, peptide:41-92, peptide:59-92, peptide:76-92, peptide:79-92, peptide:87-92, propeptide:96-101

Reference Genes

BioGPS Gene:2520 GAST

COSMIC (genes):GAST GAST

CTD Gene:2520 GAST

dbSNP Gene:2520 GAST

ENSEMBL:ENSG00000184502.4 GAST

HGNC:4164 GAST

KEGG Gene (Homo sapiens):2520 GAST

Monarch:2520 GAST

NCBI Gene:2520 GAST

OMIM:137250 GAST

UCSC:P01350 GAST

Reference Transcript

RefSeq:NM_000805.4 GAST

Other Identifiers

0007100242

11730167_at

16834189

208138_PM_at

208138_at

2520

34552_at

3721427

3721428

3721429

3721430

8007148

A_23_P159191

GE481074

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0007165

GO:0007186

GO:0023052

GO:0032094

GO:0098772

HMNXSV003029462

ILMN_1712721

M15958_at

PH_hs_0000348

TC17000515.hg

g6005999_3p_at

Participates

as an input of

Gastrin binds to CCK-B receptor (Homo sapiens)

as a member of

Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)

as a component of

Gastrin:CCKBR [plasma membrane] (Homo sapiens)

Inferred To

GAST [extracellular region] (Bos taurus)

GAST [extracellular region] (Canis familiaris)

GAST [extracellular region] (Sus scrofa)

Gast [extracellular region] (Mus musculus)

Gast [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_000796.1

OpenTargets

ENSG00000184502

HPA

ENSG00000184502-GAST

GeneCards

P01350

Ensembl

ENSP00000331358, ENST00000329402, ENSG00000184502

PRO

P01350

Pharos - Targets

P01350

PDB

5WRJ

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02787 TF	6	apoTF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869140) TF [secretory granule lumen] (R-HSA-350704) p-TF [endoplasmic reticulum lumen] (R-HSA-8957001) TF [endoplasmic reticulum lumen] (R-HSA-8956763) apoTF [endosome membrane] (R-HSA-917974) apoTF [extracellular region] (R-HSA-350754)	0.618	5
UniProt:P43628 KIR2DL3	1	KIR2DL3 [plasma membrane] (R-HSA-3006532)	0.556	3
UniProt:Q8NBJ4 GOLM1	2	p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938) GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)	0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	5
UniProt:Q4KMG9 TM52B			0.556	3
UniProt:P60201-2 PLP1			0.556	3
UniProt:P15941-11 MUC1			0.556	3
UniProt:Q5JX71 F209A			0.556	3
UniProt:Q6ZUX7 LHFPL2	2	LHFPL2 [plasma membrane] (R-HSA-8862949) LHFPL2 [platelet alpha granule membrane] (R-HSA-8862969)	0.556	3
UniProt:P00387 CYB5R3	3	CYB5R3(27-301) [azurophil granule lumen] (R-HSA-6799217) CYB5R3(27-301) [extracellular region] (R-HSA-6806205) MyrG-CYB5R3(2-301) [mitochondrial outer membrane] (R-HSA-198771)	0.556	3
UniProt:Q8TDT2 GP152			0.556	3
UniProt:O43315 AQP9	1	AQP9 [plasma membrane] (R-HSA-431761)	0.556	3
UniProt:Q9BXK5 B2L13			0.556	3
UniProt:Q13113 PDZ1I			0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:Q12797-6 ASPH			0.556	3
UniProt:Q15546 PAQRB			0.556	3
UniProt:Q8N5K1 CISD2			0.556	3
UniProt:Q14973 SLC10A1	1	SLC10A1 [plasma membrane] (R-HSA-194116)	0.556	3

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