TRIM33 monoubiquitinates SMAD4

Stable Identifier
R-HSA-870449
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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TRIM33 (also known as Ecto, Ectodermin or Tif1-gamma) monoubiquitinates nuclear SMAD4 on lysine residue K519. This leads to disruption of heterotrimeric complexes composed of SMAD4 and two phosphorylated R-SMADs (SMAD2 and/or SMAD3). TRIM33 inhibits SMAD activity without affecting steady state levels of SMAD4 (Dupont et al. 2009, Dupont et al. 2005).
Literature References
PubMed ID Title Journal Year
19135894 FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination

Stinchfield, MJ, Montagner, M, Morsut, L, Piccolo, S, Inui, M, Moro, S, Mamidi, A, Newfeld, SJ, Soligo, S, Dupont, S, Argenton, F, Martello, G, Modena, N, Adorno, M, Zacchigna, L, Cordenonsi, M

Cell 2009
15820681 Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase

Soligo, S, Dupont, S, Rugge, M, Piccolo, S, Adorno, M, Zacchigna, L, Cordenonsi, M

Cell 2005
Participants
Participates
Catalyst Activity

ubiquitin-protein transferase activity of p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
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