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USP9X [cytosol]
Stable Identifier
R-HSA-870499
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
FAM, Probable ubiquitin carboxyl-terminal hydrolase FAF-X
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
USP9X (FAM) binds to ubiquitinated SMAD4 (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
Ub-SMAD4:USP9X [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
USP9X (FAM) deubiquitinates SMAD4 (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
Ub-SMAD4:USP9X [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
USP9X binds Ub-SNCA (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
USP9X:Ub-SNCA [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
USP9X deubiquitinates Ub-SNCA (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
USP9X:Ub-SNCA [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
USPX9:SNCA [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
USP9X:SNCA dissociates (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
USPX9:SNCA [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP9X (FAM) binds to ubiquitinated SMAD4 (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
Ub-SMAD4:USP9X [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
USP9X (FAM) deubiquitinates SMAD4 (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
Ub-SMAD4:USP9X [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
Protein ubiquitination (Homo sapiens)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Homo sapiens)
UCHL3,USP7,USP9X [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Homo sapiens)
UCHL3,USP7,USP9X [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
Protein localization (Homo sapiens)
Peroxisomal protein import (Homo sapiens)
USP9X binds Ub:PEX5L (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
USP9X:Ub:PEX5L [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
USP9X binds Ub:PEX5S (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
USP9X:Ub:PEX5S [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
USP9X:Ub:PEX5L [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
USP9X:Ub:PEX5S [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOU GTPase cycle (Homo sapiens)
RHOU binds effectors at the plasma membrane (Homo sapiens)
RHOU effectors [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
RHOU:GTP:RHOU effectors [plasma membrane] (Homo sapiens)
RHOU effectors [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
RHOV GTPase cycle (Homo sapiens)
RHOV binds effectors at the plasma membrane (Homo sapiens)
RHOV effectors [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
RHOV:GTP:RHOV effectors [plasma membrane] (Homo sapiens)
RHOV effectors [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
USP9X (FAM) binds to ubiquitinated SMAD4 (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
Ub-SMAD4:USP9X [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
USP9X (FAM) deubiquitinates SMAD4 (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
Ub-SMAD4:USP9X [cytosol] (Homo sapiens)
USP9X [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q93008 USP9X
Gene Names
USP9X, DFFRX, FAM, USP9
Chain
chain:1-2554
Reference Genes
BioGPS Gene:8239 USP9X
COSMIC (genes):USP9X USP9X
CTD Gene:8239 USP9X
dbSNP Gene:8239 USP9X
ENSEMBL:ENSG00000124486 USP9X
ENSEMBL_homo_sapiens_GENE:ENSG00000124486.15 USP9X
HGNC:12632 USP9X
KEGG Gene (Homo sapiens):8239 USP9X
Monarch:8239 USP9X
NCBI Gene:8239 USP9X
OMIM:300072 USP9X
UCSC:Q93008 USP9X
Reference Transcript
RefSeq:NM_001039590.2 USP9X
RefSeq:NM_001039591.2 USP9X
Other Identifiers
11725328_a_at
11725329_a_at
11725330_a_at
11725331_a_at
11757582_s_at
17102689
201099_PM_at
201099_at
201100_PM_s_at
201100_s_at
229573_PM_at
229573_at
32572_at
3974707
3974709
3974710
3974711
3974712
3974720
3974721
3974722
3974724
3974725
3974727
3974728
3974729
3974730
3974731
3974732
3974733
3974734
3974736
3974738
3974739
3974743
3974745
3974746
3974748
3974750
3974752
3974756
3974757
3974759
3974760
3974761
3974764
3974766
3974767
3974768
3974769
3974770
3974772
3974773
3974775
3974777
3974779
3974782
3974783
3974784
3974785
3974787
3974789
3974790
3974792
3974795
3974796
3974797
3974799
3974801
3974802
3974803
3974804
3974805
3974806
3974808
4030123
4030142
4030155
63336_at
74225_at
8166826
8239
968_i_at
969_s_at
970_r_at
A_14_P138476
A_23_P217409
A_33_P3387771
GE60205
GE867920
GO:0000122
GO:0001764
GO:0003824
GO:0004197
GO:0004843
GO:0005515
GO:0005634
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005929
GO:0006281
GO:0006307
GO:0006351
GO:0006355
GO:0006508
GO:0006886
GO:0007031
GO:0007049
GO:0007059
GO:0007179
GO:0007292
GO:0008104
GO:0008233
GO:0008234
GO:0016020
GO:0016477
GO:0016562
GO:0016567
GO:0016579
GO:0016787
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0030426
GO:0030509
GO:0032092
GO:0032435
GO:0035520
GO:0036211
GO:0042752
GO:0042995
GO:0043226
GO:0044782
GO:0048511
GO:0048675
GO:0048856
GO:0048870
GO:0050821
GO:0051301
GO:0055085
GO:0060271
GO:0061578
GO:0061824
GO:0070410
GO:0070536
GO:0071947
GO:0101005
GO:0140096
GO:0140313
GO:0180017
GO:1904515
GO:1990000
GO:1990380
HMNXSV003051998
Hs.128148.0.A1_3p_at
Hs.77578.0.S2_3p_at
ILMN_1656165
ILMN_2400583
PH_hs_0004475
PH_hs_0035285
TC0X000195.hg
X98296_at
g11641424_3p_a_at
Participates
as a candidate of
RHOV effectors [cytosol] (Homo sapiens)
RHOU effectors [cytosol] (Homo sapiens)
as an input of
USP9X binds Ub:PEX5S (Homo sapiens)
USP9X binds Ub:PEX5L (Homo sapiens)
USP9X binds Ub-SNCA (Homo sapiens)
USP9X (FAM) binds to ubiquitinated SMAD4 (Homo sapiens)
as an output of
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Homo sapiens)
USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin (Homo sapiens)
USP9X:SNCA dissociates (Homo sapiens)
USP9X (FAM) deubiquitinates SMAD4 (Homo sapiens)
as a component of
USP9X:Ub:PEX5S [cytosol] (Homo sapiens)
USP9X:Ub:PEX5L [cytosol] (Homo sapiens)
USPX9:SNCA [cytosol] (Homo sapiens)
USP9X:Ub-SNCA [cytosol] (Homo sapiens)
Ub-SMAD4:USP9X [cytosol] (Homo sapiens)
as a member of
UCHL3,USP7,USP9X [cytosol] (Homo sapiens)
Inferred To
usp9x [cytosol]
(Xenopus tropicalis)
USP9X [cytosol]
(Bos taurus)
USP9X [cytosol]
(Caenorhabditis elegans)
USP9X [cytosol]
(Dictyostelium discoideum)
USP9X [cytosol]
(Mus musculus)
USP9X [cytosol]
(Sus scrofa)
USP9Y [cytosol]
(Gallus gallus)
faf [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001034680.2
,
NP_001034679.2
OpenTargets
ENSG00000124486
ZINC - Substances
USP9X_HUMAN
ZINC target
Q93008
PRO
Q93008
PDB
7YXX
,
7YXY
,
5WCH
,
5VBD
HPA
ENSG00000124486-USP9X
GeneCards
Q93008
Ensembl
ENSG00000124486
,
ENSP00000515975
,
ENSP00000367558
,
ENSP00000316357
,
ENST00000324545
,
ENST00000378308
,
ENST00000704650
Pharos - Targets
Q93008
Orphanet
22818
ZINC - Predictions - Purchasable
USP9X_HUMAN
HMDB Protein
HMDBP10126
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q07820 MCL1
1
MCL1 [cytosol]
(R-HSA-5661490)
0.679
10
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
8
UniProt:O60285 NUAK1
2
p-T211-NUAK1 [nucleoplasm]
(R-HSA-3222011)
NUAK1 [nucleoplasm]
(R-HSA-3222004)
0.564
2
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.556
3
UniProt:P49761 CLK3
0.527
2
UniProt:P29353 SHC1
5
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
SHC1 [cytosol]
(R-HSA-74680)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
0.527
3
UniProt:P49674 CSNK1E
2
CSNK1E [nucleoplasm]
(R-HSA-421306)
CSNK1E [cytosol]
(R-HSA-205877)
0.527
2
UniProt:P23771 GATA3
2
GATA3 [nucleoplasm]
(R-HSA-996768)
PolyUb-GATA3 [nucleoplasm]
(R-HSA-6783009)
0.527
2
UniProt:Q6VAB6 KSR2
1
KSR2 [cytosol]
(R-HSA-5672589)
0.527
6
UniProt:O15169 AXIN1
11
AXIN1 L396M [cytosol]
(R-HSA-5251503)
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
p-T481,S486,S493-AXIN1 [cytosol]
(R-HSA-206040)
AXIN1 [cytosol]
(R-HSA-195249)
0.527
2
UniProt:P08393 ICP0
0.499
3
UniProt:Q8IYB8 SUPV3L1
1
SUPV3L1 [mitochondrial matrix]
(R-HSA-429828)
0.483
2
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