TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus

Stable Identifier
Reaction [binding]
Homo sapiens
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E3 ubiquitin protein ligase TRIM33 (also known as Ecto, Ectodermin or Tif1-gamma) binds to the SMAD heterotrimer, composed of SMAD4 and two phosphorylated R-SMADs (SMAD2 and/or SMAD3), in the nucleus (Dupont et al. 2009, Dupont et al. 2005, He et al. 2006).

Literature References
PubMed ID Title Journal Year
19135894 FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination

Stinchfield, MJ, Montagner, M, Morsut, L, Piccolo, S, Inui, M, Moro, S, Mamidi, A, Newfeld, SJ, Soligo, S, Dupont, S, Argenton, F, Martello, G, Modena, N, Adorno, M, Zacchigna, L, Cordenonsi, M

Cell 2009
16751102 Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway

Massague, J, Moore, MA, Dorn, DC, He, W, Tempst, P, Erdjument-Bromage, H

Cell 2006
15820681 Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase

Soligo, S, Dupont, S, Rugge, M, Piccolo, S, Adorno, M, Zacchigna, L, Cordenonsi, M

Cell 2005
Orthologous Events
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