Reactome | Phosphorylation of STAT1 by JAK kinases

Phosphorylation of STAT1 by JAK kinases

Stable Identifier

R-HSA-873922

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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STAT1 pair recruited to the receptor complex is phosphorylated near the C-terminus at residue Y701, probably by JAK2. This phosphorylation enables the STAT1 homodimer formation which is further phosphorylated on residue S727.

Literature References

PubMed ID	Title	Journal	Year
7657660	Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor Witthuhn, BA, Thierfelder, W, Quelle, FW, Cohen, S, Tang, B, Ihle, JN	J Biol Chem	1995
7690989	A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma Stark, GR, Darnell JE, Jr, Kerr, IM, Shuai, K	Science	1993
8631301	Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state Witthuhn, BA, Wilks, AF, Stark, GR, Watling, D, Kerr, IM, Briscoe, J, Rogers, NC, Harpur, AG, Ihle, JN	EMBO J	1996
12040185	A road map for those who don't know JAK-STAT Horvath, CM, Aaronson, DS	Science	2002