Reactome | SUGT1 [cytosol]

SUGT1 [cytosol]

Stable Identifier

R-HSA-874107

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Suppressor of G2 allele of SKP1 homolog, SUGT1_HUMAN, SGT1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y2Z0 SUGT1

Gene Names

SUGT1

Chain

initiator methionine:, chain:2-365

Reference Genes

BioGPS Gene:10910 SUGT1

COSMIC (genes):SUGT1 SUGT1

CTD Gene:10910 SUGT1

dbSNP Gene:10910 SUGT1

ENSEMBL:ENSG00000165416 SUGT1

HGNC:16987 SUGT1

KEGG:hsa:10910 SUGT1

Monarch:10910 SUGT1

NCBI Gene:10910 SUGT1

OMIM:604098 SUGT1

UCSC:Q9Y2Z0 SUGT1

Reference Transcript

Participates

as an input of

SGT1 binds HSP90 (Homo sapiens)

as a component of

SUGT1:HSP90 [cytosol] (Homo sapiens)

Inferred To

SGT1 [cytosol] (Saccharomyces cerevisiae)

SUGT1 [cytosol] (Bos taurus)

SUGT1 [cytosol] (Canis familiaris)

SUGT1 [cytosol] (Gallus gallus)

SUGT1 [cytosol] (Sus scrofa)

Sugt1 [cytosol] (Mus musculus)

Sugt1 [cytosol] (Rattus norvegicus)

git7 [cytosol] (Schizosaccharomyces pombe)

Sgt1 [cytosol] (Drosophila melanogaster)

sugt1 [cytosol] (Danio rerio)

sugt1 [cytosol] (Dictyostelium discoideum)

sugt1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001307760.1, NP_006695.1, NP_001124384.1

OpenTargets

ENSG00000165416

ENSEMBL

ENST00000310528, ENSP00000308067, ENSG00000165416, ENSP00000367208, ENST00000343788

HPA

ENSG00000165416-SUGT1

GeneCards

SUGT1

PRO

Q9Y2Z0

Pharos - Targets

Q9Y2Z0

GlyGen

Q9Y2Z0

PDB

1RL1

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:A0A0H3NF38 A0A0H3NF38			0.737	7
UniProt:Q96II8 LRCH3			0.643	5
UniProt:Q8IW35 CEP97	1	CEP97 [cytosol] (R-HSA-5626440)	0.615	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	9
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.59	2
UniProt:O60346 PHLPP1	1	PHLPP1 [cytosol] (R-HSA-199421)	0.569	3
UniProt:Q9Y239 NOD1	1	NOD1 [cytosol] (R-HSA-168407)	0.564	5
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.527	3
UniProt:Q15404 RSU1	1	RSU1 [cytosol] (R-HSA-446297)	0.527	2
UniProt:Q14344 GNA13	1	GNA13 [plasma membrane] (R-HSA-167451)	0.527	2
UniProt:Q8N9N7 LRC57			0.527	2
UniProt:Q13309 SKP2	3	SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [cytosol] (R-HSA-975495)	0.527	3
UniProt:Q14318 FKBP8	2	PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001) FKBP8 [mitochondrial outer membrane] (R-HSA-5696928)	0.527	2
UniProt:Q8N5M4 TTC9C			0.527	2
UniProt:Q9H4P4 RNF41	1	RNF41 [cytosol] (R-HSA-975977)	0.527	2
UniProt:Q9Y2L9 LRCH1			0.527	3
UniProt:Q9UF56 FBXL17	1	FBXL17 [nucleoplasm] (R-HSA-9708570)	0.527	5
UniProt:O75427 LRCH4			0.499	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.483	4
UniProt:Q9Y3A5 SBDS			0.483	2

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