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P2X7 mediates membrane pores that include pannexin-1
Stable Identifier
R-HSA-877198
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
P2X7 mediates membrane pores that include pannexin-1 (Homo sapiens)
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At higher concentrations of extracellular ATP, the P2X7 channel acts as an inducer of nonselective macropores permeable to large (up to 800 Da) inorganic and organic molecules. These 'death complex' pores rapidly leads to complete collapse of ionic gradients, changing the cytosolic environment from high K/ low Na/ low Cl to low K/ high Na/ high Cl (Steinberg et al. 1987, Steinberg & Silverstein 1987, Kahlenberg & Dubyak 2004). The long carboxyl-terminal cytoplasmic domain of P2X7 (352-595) appears to be crucial for P2X7 pore formation (Cheewatrakoolpong et al. 2005, Adinolfi et al. 2005). P2X7 membrane pores were recently shown to include pannexin-1 (Locovei et al. 2007). Pannexins have low homology with the invertebrate innexin gap junction proteins, reported to form gap junction channels and also to function as hemi-gap junction channels that are sensitive to gap junction channel blockers (Bruzzone et al. 2003, 2005). The P2X7 receptor is generally accepted to be part of a multimeric complex, not fully characterized (Kim et al. 2001).
Literature References
PubMed ID
Title
Journal
Year
2182768
ATP-induced pore formation in the plasma membrane of rat peritoneal mast cells
Tatham, PE
,
Lindau, M
J Gen Physiol
1990
450099
ATP induces nucleotide permeability in rat mast cells
Gomperts, BD
,
Cockcroft, S
Nature
1979
17036048
Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor
Surprenant, A
,
Pelegrin, P
EMBO J
2006
Participants
Input
ATP:P2X7 oligomer [plasma membrane]
(Homo sapiens)
PANX1 [plasma membrane]
(Homo sapiens)
Output
ATP:P2X7 oligomer:Pannexin-1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
The NLRP3 inflammasome (Homo sapiens)
Orthologous Events
P2X7 mediates membrane pores that include pannexin-1 (Bos taurus)
P2X7 mediates membrane pores that include pannexin-1 (Canis familiaris)
P2X7 mediates membrane pores that include pannexin-1 (Danio rerio)
P2X7 mediates membrane pores that include pannexin-1 (Gallus gallus)
P2X7 mediates membrane pores that include pannexin-1 (Mus musculus)
P2X7 mediates membrane pores that include pannexin-1 (Rattus norvegicus)
P2X7 mediates membrane pores that include pannexin-1 (Sus scrofa)
Authored
Jupe, S (2010-04-22)
Reviewed
Kufer, TA (2011-04-28)
Rittinger, K (2011-06-06)
Wong, E (2011-06-06)
Created
Jupe, S (2010-06-11)
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