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PIAS1 [nucleoplasm]
Stable Identifier
R-HSA-877307
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
E3 SUMO-protein ligase PIAS1, PIAS1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P01023 A2M
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon gamma signaling (Homo sapiens)
Regulation of IFNG signaling (Homo sapiens)
PIAS1 binds p-STAT1 dimer (Homo sapiens)
PIAS1 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
PIAS1 SUMOylates L3MBTL2 with SUMO2 (Homo sapiens)
PIAS1 [nucleoplasm] (Homo sapiens)
PIAS1 SUMOylates SATB1 with SUMO1 (Homo sapiens)
PIAS1 [nucleoplasm] (Homo sapiens)
PIAS1 SUMOylates SATB1 with SUMO2,3 (Homo sapiens)
PIAS1 [nucleoplasm] (Homo sapiens)
PIAS1 SUMOylates SATB2 with SUMO3 (Homo sapiens)
PIAS1 [nucleoplasm] (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
PIAS1 SUMOylates NR2C1 (TR2) (Homo sapiens)
PIAS1 [nucleoplasm] (Homo sapiens)
PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Homo sapiens)
PIAS1 [nucleoplasm] (Homo sapiens)
PIAS1 SUMOylates THRB with SUMO1 (Homo sapiens)
PIAS1 [nucleoplasm] (Homo sapiens)
PIAS1 SUMOylates THRB with SUMO3 (Homo sapiens)
PIAS1 [nucleoplasm] (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
PIAS1 SUMOylates DDX5 with SUMO2 (Homo sapiens)
PIAS1 [nucleoplasm] (Homo sapiens)
PIAS1 SUMOylates SAFB with SUMO1 (Homo sapiens)
PIAS1 [nucleoplasm] (Homo sapiens)
PIAS1 SUMOylates SAFB with SUMO2,3 (Homo sapiens)
PIAS1 [nucleoplasm] (Homo sapiens)
SUMOylation of transcription factors (Homo sapiens)
PIAS1 SUMOylates SP3 with SUMO1 (Homo sapiens)
PIAS1 [nucleoplasm] (Homo sapiens)
PIAS1 SUMOylates SP3 with SUMO2 (Homo sapiens)
PIAS1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75925 PIAS1
Gene Names
PIAS1, DDXBP1
Chain
initiator methionine:, chain:2-651
Reference Genes
BioGPS Gene:8554 PIAS1
COSMIC (genes):PIAS1 PIAS1
CTD Gene:8554 PIAS1
dbSNP Gene:8554 PIAS1
ENSEMBL:ENSG00000033800 PIAS1
ENSEMBL_homo_sapiens_GENE:ENSG00000033800.14 PIAS1
HGNC:2752 PIAS1
KEGG Gene (Homo sapiens):8554 PIAS1
Monarch:8554 PIAS1
NCBI Gene:8554 PIAS1
OMIM:603566 PIAS1
UCSC:O75925 PIAS1
Reference Transcript
RefSeq:XM_017022688.1 PIAS1
RefSeq:NM_001320687.1 PIAS1
RefSeq:NM_016166.2 PIAS1
Other Identifiers
11737768_a_at
16802389
216143_PM_at
216143_at
217862_PM_at
217862_at
217863_PM_at
217863_at
217864_PM_s_at
217864_s_at
242278_PM_at
242278_at
3599330
3599331
3599333
3599341
3599366
3599367
3599370
3599372
3599376
3599384
3599388
3599389
3599390
3599392
3599393
3599395
3599400
3599401
3599402
3599403
3599404
3599405
3599406
3599407
3599408
3599409
3599410
3599411
3599412
36573_at
46559_at
55478_at
58682_at
7984453
8554
A_14_P115397
A_23_P163347
A_23_P163353
A_32_P142195
GE58693
GO:0000082
GO:0000122
GO:0000278
GO:0000976
GO:0003677
GO:0003712
GO:0003714
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005856
GO:0006351
GO:0006355
GO:0006357
GO:0007259
GO:0007283
GO:0008270
GO:0008542
GO:0012501
GO:0016605
GO:0016607
GO:0016740
GO:0016925
GO:0019789
GO:0019899
GO:0019904
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0031625
GO:0032436
GO:0033235
GO:0034399
GO:0036211
GO:0042127
GO:0043066
GO:0043226
GO:0045444
GO:0045893
GO:0046872
GO:0048856
GO:0050877
GO:0051152
GO:0060255
GO:0061665
GO:0065003
GO:0065004
GO:0140096
GO:0140110
GO:0140297
GO:1904377
HMNXSV003054447
HMNXSV003057695
Hs.250861.0.A1_3p_at
Hs.306457.0.A1_3p_at
Hs.75251.0.S2_3p_at
Hs.75251.0.S3_3p_at
ILMN_1780598
PH_hs_0004297
PH_hs_0031316
TC15000627.hg
U78524_at
g7706636_3p_a_at
Participates
as a member of
PML,TRIM27,PIAS1,2-1 [nucleoplasm] (Homo sapiens)
PIAS1,4 [nucleoplasm] (Homo sapiens)
PIAS1,3 [nucleoplasm] (Homo sapiens)
PIAS1,2-2 [nucleoplasm] (Homo sapiens)
PIAS1,3,4 [nucleoplasm] (Homo sapiens)
PIAS1,2-1 [nucleoplasm] (Homo sapiens)
UBE2I,PIAS1 [nucleoplasm] (Homo sapiens)
as a candidate of
PIAS1,3 [nucleoplasm] (Homo sapiens)
as a component of
p-STAT1 dimer:PIAS:SUMO1 [nucleoplasm] (Homo sapiens)
as an input of
PIAS1 binds p-STAT1 dimer (Homo sapiens)
Inferred To
PIAS1 [nucleoplasm]
(Bos taurus)
PIAS1 [nucleoplasm]
(Caenorhabditis elegans)
PIAS1 [nucleoplasm]
(Canis familiaris)
PIAS1 [nucleoplasm]
(Gallus gallus)
PIAS1 [nucleoplasm]
(Saccharomyces cerevisiae)
PIAS1 [nucleoplasm]
(Schizosaccharomyces pombe)
PIAS1 [nucleoplasm]
(Sus scrofa)
Pias1 [nucleoplasm]
(Mus musculus)
Pias1 [nucleoplasm]
(Rattus norvegicus)
Su(var)2-10 [nucleoplasm]
(Drosophila melanogaster)
Homologues of PIAS1 [nucleoplasm]
(Saccharomyces cerevisiae)
Cross References
RefSeq
XP_016878177.1
,
NP_057250.1
,
NP_001307616.1
OpenTargets
ENSG00000033800
GeneCards
O75925
HPA
ENSG00000033800-PIAS1
Ensembl
ENSP00000249636
,
ENSP00000438574
,
ENSG00000033800
,
ENST00000545237
,
ENST00000249636
PRO
O75925
Pharos - Targets
O75925
PDB
1V66
Interactors (53)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
19
UniProt:P54253 ATX1
0.666
7
UniProt:Q9UIS9 MBD1
2
monoSUMO1-K499,K538-MBD1 [nucleoplasm]
(R-HSA-4090331)
MBD1 [nucleoplasm]
(R-HSA-417134)
0.581
3
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.571
4
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:P51608 MECP2
0.556
3
UniProt:Q9P1N4 Q9P1N4
0.556
3
UniProt:Q9NUW8 TDP1
1
TDP1 [nucleoplasm]
(R-HSA-175593)
0.556
3
UniProt:O43933 PEX1
1
PEX1 [cytosol]
(R-HSA-9033116)
0.556
3
UniProt:P01023 A2M
2
A2M [extracellular region]
(R-HSA-49291)
A2M [platelet alpha granule lumen]
(R-HSA-139834)
0.556
3
UniProt:P35240-4 NF2
0.556
3
UniProt:A0A0S2Z5Q7 A0A0S2Z5Q7
0.556
3
UniProt:P07686 HEXB
11
HEXB S62L [lysosomal lumen]
(R-HSA-3700901)
HEXB R284* [lysosomal lumen]
(R-HSA-3700930)
HEXB M26Cfs*5 [lysosomal lumen]
(R-HSA-3700843)
HEXB I322Kfs*5 [lysosomal lumen]
(R-HSA-3700889)
HEXB(315-556) [extracellular region]
(R-HSA-6806188)
HEXB(122-311) [extracellular region]
(R-HSA-6806190)
HEXB(315-556) [azurophil granule lumen]
(R-HSA-6799134)
HEXB(122-311) [azurophil granule lumen]
(R-HSA-6799125)
HEXB(316-556) [lysosomal lumen]
(R-HSA-1605605)
HEXB(122-311) [lysosomal lumen]
(R-HSA-1605777)
HEXB(50-107) [lysosomal lumen]
(R-HSA-9842398)
0.556
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:P45381 ASPA
1
ASPA [cytosol]
(R-HSA-5691513)
0.556
3
UniProt:P48643 CCT5
1
CCT5 [cytosol]
(R-HSA-390447)
0.556
3
UniProt:P26378-2 P263782
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:P41219 PERI
0.556
3
UniProt:Q9UBB4 ATX10
0.556
3
UniProt:P54577 YARS1
1
YARS [cytosol]
(R-HSA-379560)
0.556
3
UniProt:Q6NUL7 Q6NUL7
0.556
3
UniProt:O60333-2 KIF1B
0.556
3
UniProt:P54252 ATXN3
2
ATXN3 [nucleoplasm]
(R-HSA-6783285)
ATXN3 [cytosol]
(R-HSA-5625607)
0.556
9
UniProt:P05129 PRKCG
1
PRKCG [cytosol]
(R-HSA-58204)
0.556
3
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.556
3
UniProt:Q13216-2 ERCC8
0.556
3
UniProt:P02545 LMNA
3
LMNA(1-646) [nuclear envelope]
(R-HSA-535479)
LMNA(1-567)-RAF1(279-648) fusion [cytosol]
(R-HSA-6802399)
LMNA(1-567)-p-RAF1(279-648) fusion [cytosol]
(R-HSA-6802537)
0.556
3
UniProt:G5E9A7 G5E9A7
0.556
3
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.556
3
UniProt:P28358 HXD10
0.556
3
UniProt:Q16637 SMN1
2
SMN1 [nucleoplasm]
(R-HSA-191892)
SMN1 [cytosol]
(R-HSA-191839)
0.556
3
IntAct:EBI-25865403 EHD27213144
0.556
3
UniProt:P35240 NF2
1
NF2 [plasma membrane]
(R-HSA-5669168)
0.556
3
UniProt:Q92870-2 Q928702
0.556
3
UniProt:O00628 PEX7
2
PEX7 [peroxisomal membrane]
(R-HSA-9033493)
PEX7 [cytosol]
(R-HSA-9033107)
0.556
3
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.556
3
UniProt:Q53GS7 GLE1
1
GLE1 [nucleoplasm]
(R-HSA-8932905)
0.556
3
UniProt:P29474 NOS3
9
2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane]
(R-HSA-9860783)
2xPalmC-MyrG-p-S633-NOS3 [plasma membrane]
(R-HSA-9861341)
2xPalmC-MyrG-NOS3 [endocytic vesicle membrane]
(R-HSA-535007)
2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]
(R-HSA-202139)
MyrG-NOS3 [Golgi membrane]
(R-HSA-534995)
MyrG-NOS3 [cytosol]
(R-HSA-203687)
2xPalmC-MyrG-NOS3 [plasma membrane]
(R-HSA-534993)
2xPalmC-MyrG-NOS3 [Golgi membrane]
(R-HSA-203769)
NOS3 [cytosol]
(R-HSA-202114)
0.556
3
UniProt:O43464 HTRA2
1
HTRA2 [mitochondrial intermembrane space]
(R-HSA-56655)
0.556
3
UniProt:O14832 PHYH
4
PHYH [peroxisomal matrix]
(R-HSA-389574)
PHYH(1-338) [cytosol]
(R-HSA-9033143)
PHYH(1-338) [peroxisomal matrix]
(R-HSA-9033535)
PHYH(1-30) [peroxisomal matrix]
(R-HSA-9033518)
0.556
3
UniProt:Q16595 FXN
6
FXN(42-210) [mitochondrial matrix]
(R-HSA-1299445)
FXN(1-210) [mitochondrial intermembrane space]
(R-HSA-1299451)
FXN(81-210) [mitochondrial matrix]
(R-HSA-1362390)
FXN(1-41) [mitochondrial matrix]
(R-HSA-8986117)
FXN(1-210) [mitochondrial inner membrane]
(R-HSA-1299444)
FXN(42-210) [mitochondrial inner membrane]
(R-HSA-1299454)
0.556
3
UniProt:P50897 PPT1
1
PPT1 [lysosomal lumen]
(R-HSA-5690068)
0.556
3
UniProt:Q16143 SNCB
1
SNCB [cytosol]
(R-HSA-5660390)
0.556
3
UniProt:P02545-2 LMNA
5
LMNA-2 [nuclear envelope]
(R-HSA-912378)
p-S22, S395-LMNA-2 [nucleoplasm]
(R-HSA-5229019)
p-S395-LMNA-2 [nucleoplasm]
(R-HSA-5228740)
Lamin C [nucleoplasm]
(R-HSA-264872)
LMNA-2 [cytosol]
(R-HSA-2995387)
0.556
3
UniProt:Q13485 SMAD4
20
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 G352* [cytosol]
(R-HSA-9678445)
SMAD4 S178* [cytosol]
(R-HSA-9675630)
SMAD4 G477* [cytosol]
(R-HSA-9678447)
SMAD4 G473* [cytosol]
(R-HSA-9678440)
SMAD4 S144* [cytosol]
(R-HSA-9675625)
SMAD4 E538* [cytosol]
(R-HSA-9675626)
SMAD4 E390* [cytosol]
(R-HSA-9675620)
SMAD4 S154* [cytosol]
(R-HSA-9675621)
SMAD4 E330* [cytosol]
(R-HSA-9675622)
0.553
2
UniProt:O75626 PRDM1
1
PRDM1 [nucleoplasm]
(R-HSA-6804199)
0.524
2
UniProt:P11308 ERG
0.519
2
UniProt:Q9UKL3 CASP8AP2
2
monoSUMO1-K1813-CASP8AP2 [nucleoplasm]
(R-HSA-3927850)
CASP8AP2 [nucleoplasm]
(R-HSA-3927945)
0.508
4
UniProt:G2XKQ0 SUMO5
0.488
2
UniProt:P03118 VE2
0.488
2
UniProt:P48431 SOX2
1
SOX2 [nucleoplasm]
(R-HSA-452271)
0.483
2
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