Reactome | IFNAR2-2 [plasma membrane]

IFNAR2-2 [plasma membrane]

Stable Identifier

R-HSA-877333

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

IFNAR2c, Interferon alpha/beta receptor 2, INAR2_HUMAN, IFNAR2 isoform 2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P48551-2 IFNAR2

Gene Names

IFNAR2, IFNABR, IFNARB

Other Identifiers

11724685_x_at

11724686_x_at

11749121_a_at

1568_s_at

1569_r_at

1588_at

1589_s_at

16922222

16922241

204785_PM_x_at

204785_x_at

204786_PM_s_at

204786_s_at

227125_PM_at

227125_at

3455

3918479

3918490

3918491

3918492

3918493

3918496

3918497

3918499

3918502

3918503

3918510

3918511

3918512

3918513

3918514

3918515

3918534

3918536

3918537

3918538

3918539

3918540

3918541

8068238

A_23_P211080

A_33_P3337540

A_33_P3361457

GE80961

GE88322

GO:0002376

GO:0004905

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0007166

GO:0007259

GO:0008269

GO:0009615

GO:0016020

GO:0019901

GO:0019955

GO:0019962

GO:0023052

GO:0035455

GO:0035456

GO:0035458

GO:0042018

GO:0046425

GO:0051607

GO:0060089

GO:0060090

GO:0060337

GO:0098542

GO:0098586

GO:0140865

HMNXSV003010434

HMNXSV003047000

Hs.237955.1.A1_3p_at

ILMN_1765146

ILMN_1791057

ILMN_2347999

L42243_cds1_at

PH_hs_0026732

TC21001060.hg

g4504600_3p_a_at

g4504600_3p_x_at

g995296_3p_a_at

Participates

as a component of

as an input of

UBP43 binds IFNAR2 and prevents JAK1 interaction (Homo sapiens)

Inferred To

Homologues of IFNAR2-2 [plasma membrane] (Danio rerio)

Homologues of IFNAR2-2 [plasma membrane] (Xenopus tropicalis)

ifnlr1 [plasma membrane] (Xenopus tropicalis)

IFNAR2-2 [plasma membrane] (Gallus gallus)

il22ra1 [plasma membrane] (Xenopus tropicalis)

CRFB6 [plasma membrane] (Danio rerio)

Ifnar2 [plasma membrane] (Mus musculus)

Ifnar2 [plasma membrane] (Rattus norvegicus)

CRFB7 [plasma membrane] (Danio rerio)

IFNAR2 [plasma membrane] (Bos taurus)

IFNAR2 [plasma membrane] (Canis familiaris)

IFNAR2 [plasma membrane] (Sus scrofa)

ifnar2.2 [plasma membrane] (Xenopus tropicalis)

crfb9 [plasma membrane] (Danio rerio)

zgc:136623 [plasma membrane] (Danio rerio)

CRFB4 [plasma membrane] (Danio rerio)

crfb14 [plasma membrane] (Danio rerio)

il10ra [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001276054.1, NP_001276055.1, NP_001276057.1, NP_000865.2, NP_997467.1, NP_997468.1

Guide to Pharmacology - Targets

1724

OpenTargets

ENSG00000159110

GeneCards

P48551

HPA

ENSG00000159110-IFNAR2

Ensembl

ENST00000342136, ENSP00000371699, ENSP00000343289, ENSP00000343957, ENST00000342101, ENST00000404220, ENSP00000384309, ENSP00000508013, ENSG00000159110, ENST00000683941, ENST00000382264

PRO

P48551

Pharos - Targets

P48551

Orphanet

24612

PDB

3SE4, 2HYM, 1N6V, 1N6U, 3SE3, 2KZ1, 3S9D, 3S8W, 2LAG

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52630 STAT2	4	p-Y690-STAT2 [cytosol] (R-HSA-909683) STAT2 [cytosol] (R-HSA-882029) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673) p-Y-STAT2 [cytosol] (R-HSA-8987235)	0.688	4
UniProt:Q00978 IRF9	2	IRF9 [nucleoplasm] (R-HSA-913522) IRF9 [cytosol] (R-HSA-879183)	0.623	6
UniProt:P23458 JAK1	6	p-Y1034,Y1035-JAK1 [cytosol] (R-HSA-9005335) JAK1 [endosome] (R-HSA-8983168) p-JAK1 [cytosol] (R-HSA-8950711) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) JAK1 [cytosol] (R-HSA-451898) p-Y-JAK1 [cytosol] (R-HSA-451921)	0.591	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.581	4
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.576	4
UniProt:P42224 STAT1	8	p-STAT1 [nucleoplasm] (R-HSA-8987140) p-STAT1 [cytosol] (R-HSA-8950418) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622)	0.499	2

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