Reactome | IFNAR2-2 [plasma membrane]

IFNAR2-2 [plasma membrane]

Stable Identifier

R-HSA-877333

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

IFNAR2c, Interferon alpha/beta receptor 2, INAR2_HUMAN, IFNAR2 isoform 2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P48551-2 IFNAR2

Gene Names

IFNAR2, IFNABR, IFNARB

Other Identifiers

11724685_x_at

11724686_x_at

11749121_a_at

1568_s_at

1569_r_at

1588_at

1589_s_at

16922222

16922241

204785_PM_x_at

204785_x_at

204786_PM_s_at

204786_s_at

227125_PM_at

227125_at

3455

3918479

3918480

3918490

3918491

3918492

3918493

3918494

3918495

3918496

3918497

3918498

3918499

3918500

3918501

3918502

3918503

3918504

3918505

3918506

3918507

3918508

3918509

3918510

3918511

3918512

3918513

3918514

3918515

3918534

3918536

3918537

3918538

3918539

3918540

3918541

8068238

A_23_P211080

A_33_P3337540

A_33_P3361457

GE80961

GE88322

GO:0004905

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0007166

GO:0007259

GO:0008269

GO:0009615

GO:0016020

GO:0019901

GO:0019955

GO:0019962

GO:0035455

GO:0035456

GO:0035458

GO:0042018

GO:0046425

GO:0051607

GO:0060089

GO:0060090

GO:0060337

GO:0098542

GO:0098586

GO:0140865

HMNXSV003010434

HMNXSV003047000

Hs.237955.1.A1_3p_at

ILMN_1765146

ILMN_1791057

ILMN_2347999

L42243_cds1_at

PH_hs_0026732

TC21001060.hg

g4504600_3p_a_at

g4504600_3p_x_at

g995296_3p_a_at

Participates

as a component of

as an input of

UBP43 binds IFNAR2 and prevents JAK1 interaction (Homo sapiens)

Inferred To

Homologues of IFNAR2-2 [plasma membrane] (Danio rerio)

Homologues of IFNAR2-2 [plasma membrane] (Xenopus tropicalis)

Ifnar2 [plasma membrane] (Mus musculus)

Ifnar2 [plasma membrane] (Rattus norvegicus)

ifnlr1 [plasma membrane] (Danio rerio)

ifnlr1 [plasma membrane] (Xenopus tropicalis)

IFNAR2-2 [plasma membrane] (Gallus gallus)

ifngr2 [plasma membrane] (Danio rerio)

IFNAR2 [plasma membrane] (Bos taurus)

IFNAR2 [plasma membrane] (Canis familiaris)

IFNAR2 [plasma membrane] (Sus scrofa)

ifnar2.2 [plasma membrane] (Xenopus tropicalis)

crfb12 [plasma membrane] (Danio rerio)

il22ra1 [plasma membrane] (Xenopus tropicalis)

crfb4 [plasma membrane] (Danio rerio)

il22ra2 [plasma membrane] (Danio rerio)

il10ra [plasma membrane] (Danio rerio)

il10ra [plasma membrane] (Xenopus tropicalis)

Cross References

Guide to Pharmacology - Targets

1724

ENSEMBL

ENSP00000508013, ENSP00000343289, ENSG00000159110, ENST00000342101, ENST00000342136, ENSP00000371699, ENST00000404220, ENSP00000343957, ENSP00000384309, ENST00000382264, ENST00000683941

OpenTargets

ENSG00000159110

GeneCards

IFNAR2

HPA

ENSG00000159110-IFNAR2

PRO

P48551

Pharos - Targets

P48551

Orphanet

IFNAR2

PDB

3SE3, 3S9D, 2KZ1, 2HYM, 3SE4, 3S8W, 2LAG, 1N6U, 1N6V

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52630 STAT2	4	p-Y690-STAT2 [cytosol] (R-HSA-909683) STAT2 [cytosol] (R-HSA-882029) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673) p-Y-STAT2 [cytosol] (R-HSA-8987235)	0.688	4
UniProt:Q00978 IRF9	2	IRF9 [nucleoplasm] (R-HSA-913522) IRF9 [cytosol] (R-HSA-879183)	0.623	6
UniProt:P23458 JAK1	6	p-Y-JAK1 [cytosol] (R-HSA-451921) JAK1 [cytosol] (R-HSA-451898) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) p-JAK1 [cytosol] (R-HSA-8950711) JAK1 [endosome] (R-HSA-8983168) p-Y1034,Y1035-JAK1 [cytosol] (R-HSA-9005335)	0.591	3
UniProt:P63244 RACK1	1	RACK1 [cytosol] (R-HSA-5626956)	0.581	4
UniProt:Q92793 CREBBP	4	CREBBP [nucleoplasm] (R-HSA-193545) CREBBP [cytosol] (R-HSA-9756493) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.576	4
UniProt:P42224 STAT1	8	STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140)	0.499	2

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