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CAPZA1 [cytosol]
Stable Identifier
R-HSA-879363
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
F-actin-capping protein subunit alpha-1, CAZA1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P47756 CAPZB
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
Expression of capping actin protein of muscle Z-line alpha subunit 1 (Homo sapiens)
CAPZA1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P52907 CAPZA1
Gene Names
CAPZA1, capping actin protein of muscle Z-line alpha subunit 1
Chain
initiator methionine:, chain:2-286
Reference Genes
BioGPS Gene:829 CAPZA1
COSMIC (genes):CAPZA1 CAPZA1
CTD Gene:829 CAPZA1
dbSNP Gene:829 CAPZA1
ENSEMBL:ENSG00000116489 CAPZA1
HGNC:1488 CAPZA1
KEGG:hsa:829 CAPZA1
Monarch:829 CAPZA1
NCBI Gene:829 CAPZA1
OMIM:601580 CAPZA1
UCSC:P52907 CAPZA1
Reference Transcript
RefSeq:NM_006135.2 CAPZA1
Other Identifiers
11739005_at
11739006_x_at
11739007_at
11739008_x_at
16668798
208374_PM_s_at
208374_s_at
2352234
2352235
2352236
2352247
2352248
2352249
2352250
2352253
2352255
2352257
2352258
2352259
2352260
2352263
2352264
2352265
2352266
2352267
2352268
2352269
2352274
40910_at
74743_f_at
7904036
829
A_24_P310894
A_24_P379379
GE62127
GO:0003779
GO:0005515
GO:0005576
GO:0005737
GO:0005829
GO:0005856
GO:0007010
GO:0008092
GO:0008290
GO:0015629
GO:0030036
GO:0030863
GO:0034329
GO:0034330
GO:0043226
GO:0045296
GO:0051015
GO:0051016
GO:0051693
GO:0065003
GO:0070062
GO:0071203
HMNXSV003044708
Hs.247811.0.S1_3p_s_at
PH_hs_0029720
TC01000990.hg
TC01004629.hg
U56637_at
g5453596_3p_a_at
Participates
as an output of
Expression of capping actin protein of muscle Z-line alpha subunit 1 (Homo sapiens)
as a member of
F-actin capping protein alpha subunit [cytosol] (Homo sapiens)
as a component of
CAPZA1:CAPZB [cytosol] (Homo sapiens)
Other forms of this molecule
CAPZA1(265-276) [extracellular region]
Inferred To
acpB [cytosol]
(Dictyostelium discoideum)
acp1 [cytosol]
(Schizosaccharomyces pombe)
capza1 [cytosol]
(Xenopus tropicalis)
capza1b [cytosol]
(Danio rerio)
Capza1 [cytosol]
(Mus musculus)
Capza1 [cytosol]
(Rattus norvegicus)
LOC612266 [cytosol]
(Canis familiaris)
cpa [cytosol]
(Drosophila melanogaster)
cap-1 [cytosol]
(Caenorhabditis elegans)
CAP1 [cytosol]
(Saccharomyces cerevisiae)
CAPZA1 [cytosol]
(Bos taurus)
CAPZA1 [cytosol]
(Gallus gallus)
CAPZA1 [cytosol]
(Plasmodium falciparum)
CAPZA1 [cytosol]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000263168
,
ENSP00000263168
OpenTargets
ENSG00000116489
HPA
ENSG00000116489-CAPZA1
PRO
P52907
Pharos - Targets
P52907
GlyGen
P52907
PDB
1MQ1
,
1MWN
,
8F8Q
,
7T5Q
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [plasma membrane]
(R-HSA-182955)
SH3KBP1 [cytosol]
(R-HSA-182957)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.773
7
UniProt:Q13561 DCTN2
1
DCTN2 [cytosol]
(R-HSA-380302)
0.725
5
UniProt:P47756 CAPZB
1
CAPZB [cytosol]
(R-HSA-879409)
0.669
4
UniProt:P47755 CAPZA2
2
CAPZA2(265-276) [extracellular region]
(R-HSA-879417)
CAPZA2 [cytosol]
(R-HSA-879448)
0.643
5
UniProt:Q14203 DCTN1
7
DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711969)
DCTN1(1-599)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711960)
DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9701997)
DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711959)
DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711953)
DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711962)
DCTN1 [cytosol]
(R-HSA-535580)
0.638
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
21
UniProt:P04271 S100B
1
S100B [extracellular region]
(R-HSA-879433)
0.611
3
UniProt:Q9UFF9 CNOT8
1
CNOT8 [cytosol]
(R-HSA-429979)
0.564
2
UniProt:P33763 S10A5
0.544
2
UniProt:P23297 S100A1
1
S100A1 [extracellular region]
(R-HSA-6805991)
0.544
2
UniProt:P25815 S100P
2
S100P [extracellular region]
(R-HSA-6804809)
S100P [secretory granule lumen]
(R-HSA-6804782)
0.544
2
UniProt:A5YKK6 CNOT1
1
CNOT1 [cytosol]
(R-HSA-429892)
0.527
2
UniProt:Q15691 MAPRE1
1
MAPRE1 [cytosol]
(R-HSA-376240)
0.527
2
UniProt:Q6JBY9 CPZIP
0.527
3
UniProt:Q53GL0 PKHO1
0.527
3
UniProt:Q12768 WASC5
0.527
2
UniProt:Q9C0C2 TNKS1BP1
1
TNKS1BP1 [cytosol]
(R-HSA-430011)
0.527
3
UniProt:Q7KZI7 MARK2
0.527
2
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
4
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.462
2
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