Reactome | CAPZB [cytosol]

CAPZB [cytosol]

Stable Identifier

R-HSA-879409

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

F-actin-capping protein subunit beta, CAPZB_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O75175 CNOT3

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External Reference Information

External Reference

UniProt:P47756 CAPZB

Gene Names

CAPZB

Chain

initiator methionine:, chain:2-272

Reference Genes

BioGPS Gene:832 CAPZB

COSMIC (genes):CAPZB CAPZB

CTD Gene:832 CAPZB

dbSNP Gene:832 CAPZB

ENSEMBL:ENSG00000077549 CAPZB

HGNC:1491 CAPZB

KEGG:hsa:832 CAPZB

Monarch:832 CAPZB

NCBI Gene:832 CAPZB

OMIM:601572 CAPZB

UCSC:P47756 CAPZB

Reference Transcript

Other Identifiers

11720600_a_at

16682704

201949_3p_x_at

201949_PM_x_at

201949_x_at

201950_PM_x_at

201950_x_at

2399766

2399767

2399768

2399769

2399770

2399771

2399772

2399773

2399774

2399775

2399776

2399777

2399778

2399779

2399780

2399781

2399782

2399783

2399784

2399785

2399786

2399787

2399788

2399789

2399798

2399799

2399800

2399801

2399802

2399811

2399812

2399813

2399814

2399815

2399816

2399821

2399822

2399829

2399833

2399834

2399835

2399844

2399854

2399855

2399860

2399861

37012_PM_at

37012_at

4901305_3p_s_at

7913169

79967_at

832

A_23_P126752

A_33_P3235561

A_33_P3235562

A_33_P3235568

GE61350

GE85982

GO:0000902

GO:0003779

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005903

GO:0007010

GO:0008092

GO:0008154

GO:0008290

GO:0010591

GO:0014069

GO:0015629

GO:0016020

GO:0022604

GO:0030017

GO:0030027

GO:0030030

GO:0030032

GO:0030036

GO:0030863

GO:0032279

GO:0043226

GO:0045296

GO:0051015

GO:0051016

GO:0051490

GO:0051693

GO:0070062

GO:0071203

GO:0098685

GO:0098686

HMNXSV003011056

Hs.76368.0.S2_3p_s_at

ILMN_2053921

PH_hs_0016331

TC01002300.hg

TC01005305.hg

g4826658_3p_s_at

Participates

as a candidate of

as an input of

F-actin capping protein is a heterodimer (Homo sapiens)

as a component of

Inferred To

CAP2 [cytosol] (Saccharomyces cerevisiae)

cpb [cytosol] (Drosophila melanogaster)

capzb [cytosol] (Xenopus tropicalis)

CAPZB [cytosol] (Bos taurus)

CAPZB [cytosol] (Canis familiaris)

CAPZB [cytosol] (Gallus gallus)

CAPZB [cytosol] (Plasmodium falciparum)

CAPZB [cytosol] (Sus scrofa)

acpA [cytosol] (Dictyostelium discoideum)

cap-2 [cytosol] (Caenorhabditis elegans)

Capzb [cytosol] (Mus musculus)

Capzb [cytosol] (Rattus norvegicus)

acp2 [cytosol] (Schizosaccharomyces pombe)

Cross References

OpenTargets

ENSG00000077549

ENSEMBL

ENSP00000264202, ENST00000674432, ENSP00000364284, ENSP00000501528, ENST00000264202, ENST00000375142

HPA

ENSG00000077549-CAPZB

PRO

P47756

Pharos - Targets

P47756

GlyGen

P47756

PDB

8F8Q

Interactors (56)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14203 DCTN1	7	DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711969) DCTN1(1-599)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711960) DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol] (R-HSA-9701997) DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711959) DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711953) DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711962) DCTN1 [cytosol] (R-HSA-535580)	0.725	6
UniProt:Q13561 DCTN2	1	DCTN2 [cytosol] (R-HSA-380302)	0.725	6
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.725	23
UniProt:P52907 CAPZA1	2	CAPZA1(265-276) [extracellular region] (R-HSA-879421) CAPZA1 [cytosol] (R-HSA-879363)	0.669	4
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.643	5
UniProt:Q9C0C2 TNKS1BP1	1	TNKS1BP1 [cytosol] (R-HSA-430011)	0.643	5
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.615	3
UniProt:P23508 CRCM			0.564	2
UniProt:Q6IBS0 TWF2	1	TWF2 [cytosol] (R-HSA-9663291)	0.564	2
UniProt:P0DTD1-PRO_0000449628 REP			0.547	2
UniProt:O75175 CNOT3	1	CNOT3 [cytosol] (R-HSA-429872)	0.527	3
UniProt:Q9H9A5 CNOT10	1	CNOT10 [cytosol] (R-HSA-429878)	0.527	3
UniProt:O95425 SVIL			0.527	3
UniProt:Q9Y4E1 WAC2C			0.527	3
UniProt:Q9Y5K6 CD2AP	1	CD2AP [cytosol] (R-HSA-373620)	0.527	3
UniProt:Q9Y3C0 WASC3			0.527	3
UniProt:Q12768 WASC5			0.527	3
UniProt:O75935 DCTN3	1	DCTN3 [cytosol] (R-HSA-380264)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P27448 MARK3	1	MARK3 [cytosol] (R-HSA-5672591)	0.527	2
UniProt:Q92600 RQCD1	2	RQCD1 [nucleoplasm] (R-HSA-6810130) RQCD1 [cytosol] (R-HSA-430029)	0.527	3
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.527	2
UniProt:Q5VZK9 CARMIL1	1	LRRC16A [cytosol] (R-HSA-994131)	0.527	3
UniProt:Q96P48 ARAP1	2	ARAP1 [cytosol] (R-HSA-3211582) p-Y231-ARAP1 [cytosol] (R-HSA-8848869)	0.527	3
UniProt:Q2M389 WASC4			0.527	3
UniProt:Q12792 TWF1	1	TWF1 [cytosol] (R-HSA-9667687)	0.527	2
UniProt:Q9BY89 K1671			0.527	3
UniProt:Q9NZ32 ACTR10	4	ACTR10 [cytosol] (R-HSA-6801556) ACTR10 [ficolin-1-rich granule lumen] (R-HSA-6801072) ACTR10 [extracellular region] (R-HSA-6806245) ACTR10 [azurophil granule lumen] (R-HSA-6801080)	0.527	3
UniProt:Q641Q2 WAC2A			0.527	2
UniProt:Q9UKZ1 CNOT11	1	CNOT11 [cytosol] (R-HSA-429981)	0.527	3
UniProt:Q9UIV1 CNOT7	1	CNOT7 [cytosol] (R-HSA-429877)	0.527	3
UniProt:Q9NZN8 CNOT2	1	CNOT2 [cytosol] (R-HSA-429902)	0.527	3
UniProt:Q6ZU35 CRACD			0.527	3
UniProt:Q8TD55 PLEKHO2	2	PLEKHO2 [extracellular region] (R-HSA-6806484) PLEKHO2 [ficolin-1-rich granule lumen] (R-HSA-6801067)	0.527	3
UniProt:Q9UFF9 CNOT8	1	CNOT8 [cytosol] (R-HSA-429979)	0.527	2
UniProt:Q9H3G5 CPVL			0.527	2
UniProt:Q53GL0 PKHO1			0.527	3
UniProt:Q9ULJ8 NEB1			0.527	2
UniProt:P58546 MTPN			0.527	2
UniProt:O00399 DCTN6	1	DCTN6 [cytosol] (R-HSA-2029035)	0.527	3
UniProt:Q9UJW0 DCTN4	1	DCTN4 [cytosol] (R-HSA-2029070)	0.527	3
UniProt:Q9BTE1 DCTN5	1	DCTN5 [cytosol] (R-HSA-2029012)	0.527	4
UniProt:P53355 DAPK1	1	DAPK1 [cytosol] (R-HSA-418262)	0.527	3
UniProt:P47755 CAPZA2	2	CAPZA2(265-276) [extracellular region] (R-HSA-879417) CAPZA2 [cytosol] (R-HSA-879448)	0.527	4
UniProt:Q9ULM6 CNOT6	2	CNOT6 [nucleoplasm] (R-HSA-6810131) CNOT6 [cytosol] (R-HSA-429930)	0.527	3
UniProt:Q9Y3L3 SH3BP1	1	SH3BP1 [cytosol] (R-HSA-3006458)	0.527	3
UniProt:P61163 ACTR1A	1	ACTR1A [cytosol] (R-HSA-380258)	0.527	3
UniProt:P42025 ACTR1B	4	ACTR1B [cytosol] (R-HSA-2228745) ACTR1B [ficolin-1-rich granule lumen] (R-HSA-6801063) ACTR1B [extracellular region] (R-HSA-6806503) ACTR1B [secretory granule lumen] (R-HSA-6801082)	0.527	3
UniProt:Q9Y4B5 MTCL1			0.527	3
UniProt:Q6F5E8 CARL2			0.527	3
UniProt:A5YKK6 CNOT1	1	CNOT1 [cytosol] (R-HSA-429892)	0.527	3
UniProt:Q96LI5 CNOT6L	1	CNOT6L [cytosol] (R-HSA-430027)	0.527	3
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.483	2
UniProt:P23396 RPS3	2	RPS3 [cytosol] (R-HSA-72369) RPS3 [nucleoplasm] (R-HSA-6798714)	0.483	2
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.483	2
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE			0.462	2

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