Reactome | CAPZA1(265-276) [extracellular region]

CAPZA1(265-276) [extracellular region]

Stable Identifier

R-HSA-879421

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

F-actin-capping protein subunit alpha-1 fragment TRTK-12, TRTK-12, CAPZA1, CAZA1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P52907 CAPZA1

Gene Names

CAPZA1, capping actin protein of muscle Z-line alpha subunit 1

Chain

initiator methionine:, chain:2-286

Reference Genes

BioGPS Gene:829 CAPZA1

COSMIC (genes):CAPZA1 CAPZA1

CTD Gene:829 CAPZA1

dbSNP Gene:829 CAPZA1

ENSEMBL:ENSG00000116489 CAPZA1

ENSEMBL_homo_sapiens_GENE:ENSG00000116489.13 CAPZA1

HGNC:1488 CAPZA1

KEGG Gene (Homo sapiens):829 CAPZA1

Monarch:829 CAPZA1

NCBI Gene:829 CAPZA1

OMIM:601580 CAPZA1

UCSC:P52907 CAPZA1

Reference Transcript

RefSeq:NM_006135.2 CAPZA1

Other Identifiers

11739005_at

11739006_x_at

11739007_at

11739008_x_at

208374_PM_s_at

208374_s_at

2352235

2352236

2352248

2352249

2352253

2352255

2352257

2352260

2352264

2352265

2352267

2352268

2352269

2352274

40910_at

74743_f_at

7904036

829

A_24_P310894

GE62127

GO:0003779

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005856

GO:0007010

GO:0008092

GO:0008290

GO:0015629

GO:0030036

GO:0034329

GO:0034330

GO:0043226

GO:0045296

GO:0051015

GO:0051016

GO:0051693

GO:0065003

GO:0070062

GO:0071203

HMNXSV003044708

PH_hs_0029720

TC01000990.hg

TC01004629.hg

U56637_at

g5453596_3p_a_at

Participates

as a member of

F-actin capping protein alpha protein fragment TRTK-12 [extracellular region] (Homo sapiens)

Other forms of this molecule

CAPZA1 [cytosol]

Inferred To

cap-1 [extracellular region] (Caenorhabditis elegans)

acp1 [extracellular region] (Schizosaccharomyces pombe)

capza1 [extracellular region] (Xenopus tropicalis)

LOC612266 [extracellular region] (Canis familiaris)

Capza1 [extracellular region] (Mus musculus)

Capza1 [extracellular region] (Rattus norvegicus)

acpB [extracellular region] (Dictyostelium discoideum)

capza1b [extracellular region] (Danio rerio)

CAP1 [extracellular region] (Saccharomyces cerevisiae)

CAPZA1(265-276) [extracellular region] (Plasmodium falciparum)

CAPZA1 [extracellular region] (Bos taurus)

CAPZA1 [extracellular region] (Gallus gallus)

CAPZA1 [extracellular region] (Sus scrofa)

cpa [extracellular region] (Drosophila melanogaster)

Cross References

RefSeq

NP_006126.1

OpenTargets

ENSG00000116489

HPA

ENSG00000116489-CAPZA1

GeneCards

P52907

Ensembl

ENSG00000116489, ENST00000263168, ENSP00000263168

PRO

P52907

Pharos - Targets

P52907

PDB

8F8Q, 1MQ1, 7T5Q, 1MWN

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.773	7
UniProt:Q13561 DCTN2	1	DCTN2 [cytosol] (R-HSA-380302)	0.725	5
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.669	4
UniProt:P47755 CAPZA2	2	CAPZA2 [cytosol] (R-HSA-879448) CAPZA2(265-276) [extracellular region] (R-HSA-879417)	0.643	5
UniProt:Q14203 DCTN1	7	DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711969) DCTN1(1-599)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711960) DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol] (R-HSA-9701997) DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711959) DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711953) DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711962) DCTN1 [cytosol] (R-HSA-535580)	0.638	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	21
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.611	3
UniProt:Q9UFF9 CNOT8	1	CNOT8 [cytosol] (R-HSA-429979)	0.564	2
UniProt:P25815 S100P	2	S100P [extracellular region] (R-HSA-6804809) S100P [secretory granule lumen] (R-HSA-6804782)	0.544	2
UniProt:P23297 S100A1	1	S100A1 [extracellular region] (R-HSA-6805991)	0.544	2
UniProt:P33763 S10A5			0.544	2
UniProt:A5YKK6 CNOT1	1	CNOT1 [cytosol] (R-HSA-429892)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q7KZI7 MARK2			0.527	2
UniProt:Q9C0C2 TNKS1BP1	1	TNKS1BP1 [cytosol] (R-HSA-430011)	0.527	3
UniProt:Q12768 WASC5			0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4
UniProt:Q53GL0 PKHO1			0.527	3
UniProt:Q6JBY9 CPZIP			0.527	3
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.527	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2

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