F-actin capping protein is a heterodimer

Stable Identifier
R-HSA-879459
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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F-actin capping protein is a heterodimer
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F-actin-capping protein binds in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits. Unlike other capping proteins (such as gelsolin and severin), they do not sever actin filaments.
Literature References
PubMed ID Title Journal Year
9331217 Vertebrates have conserved capping protein alpha isoforms with specific expression patterns

Hart, MC, Korshunova, YO, Cooper, JA

Cell Motil Cytoskeleton 1997
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Orthologous Events
F-actin capping protein is a heterodimer (Bos taurus)
F-actin capping protein is a heterodimer (Caenorhabditis elegans)
F-actin capping protein is a heterodimer (Canis familiaris)
F-actin capping protein is a heterodimer (Dictyostelium discoideum)
F-actin capping protein is a heterodimer (Drosophila melanogaster)
F-actin capping protein is a heterodimer (Gallus gallus)
F-actin capping protein is a heterodimer (Mus musculus)
F-actin capping protein is a heterodimer (Plasmodium falciparum)
F-actin capping protein is a heterodimer (Rattus norvegicus)
F-actin capping protein is a heterodimer (Saccharomyces cerevisiae)
F-actin capping protein is a heterodimer (Schizosaccharomyces pombe)
F-actin capping protein is a heterodimer (Sus scrofa)
F-actin capping protein is a heterodimer (Xenopus tropicalis)
Authored
Akkerman, JW  (2010-10-29)
Reviewed
Ouwehand, WH  (2010-11-12)
Created
Jupe, S  (2010-06-17)
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