Reactome | SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol

SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol

Stable Identifier

R-HSA-879575

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol

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Three organic anion transporting polypeptides (OATPs; now called solute carrier organic anion transporters, SLCOs) are able to mediate the transport of thyroid hormones, predominantly thyroxine (T4) and triiodothyronine (T3) (Fujiwara et al. 2001). SLCO1B1 (formerly OATP-C), which can also transport bile salts, is mainly expressed in the liver (Abe et al. 1999; Hsiang et al. 1999). SLCO4A1 (formerly OATP-E) is mainly expressed in peripheral tissue and has a broad substrate specificty (Tamai et al. 2000). SLCO1C1 (formerly OATP-F) is highly expressed in brain and is also a high affinity thyroid hormone transporter (Pizzagalli et al. 2002).

The monocarboxylate transporter 8 (MCT8, SLC16A2 is also a very active and specific thyroid hormone transporter in its dimeric form (Visser et al. 2009). Defects in SLC16A2 can cause severe X-linked psychomotor retardation. SLC16A2 mutations that inhibited SLC16A2 dimerisation resulted in defective transport function of SLC16A2 (Fischer et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
12351693	Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter Klenk, U, Folkers, G, Meier, PJ, Hagenbuch, B, Stieger, B, Pizzagalli, F	Mol Endocrinol	2002
10873595	Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family Shimane, M, Sai, Y, Tamai, I, Tsuji, A, Uchino, H, Oku, A, Nezu, J	Biochem Biophys Res Commun	2000
10358072	Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1 Unno, M, Naitoh, T, Yawo, H, Tokui, T, Nishio, T, Abe, T, Suzuki, M, Nakagomi, R, Nakai, D, Nomura, H, Kakyo, M, Matsuno, S	J Biol Chem	1999
19797118	Evidence for a homodimeric structure of human monocarboxylate transporter 8 Ianculescu, AG, Klootwijk, W, Philp, NJ, Jansen, J, Visser, TJ, Friesema, EC, Beesley, PW, van Dijk, TB, Visser, WE	Endocrinology	2009
10601278	A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters Yang, WP, Wu, Y, Hsiang, B, Sasseville, V, Kirchgessner, TG, Wang, Z, Zhu, Y	J Biol Chem	1999
25527620	Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations Kleinau, G, Kühnen, P, Rehders, M, Fischer, J, Kinne, A, Brix, K, Gruters, A, Zwanziger, D, Müller, A, Führer, D, Moeller, LC, Biebermann, H, Krude, H	J. Mol. Endocrinol.	2015
11316767	Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner Unno, M, Onogawa, T, Fujiwara, K, Tokui, T, Okabe, M, Nishio, T, Seki, M, Kondo, Y, Tanemoto, M, Suzuki, T, Nunoki, K, Asano, N, Abe, T, Shimosegawa, T, Suzuki, M, Shiiba, K, Adachi, H, Ito, S, Iinuma, K, Matsuno, S	Endocrinology	2001