Reactome | BHLHE40 [nucleoplasm]

BHLHE40 [nucleoplasm]

Stable Identifier

R-HSA-879741

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Class E basic helix-loop-helix protein 40, BHE40_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O14503 BHLHE40

Gene Names

BHLHE40, BHLHB2, DEC1, SHARP2, STRA13

Chain

chain:1-412

Reference Genes

BioGPS Gene:8553 BHLHE40

COSMIC (genes):BHLHE40 BHLHE40

CTD Gene:8553 BHLHE40

dbSNP Gene:8553 BHLHE40

ENSEMBL:ENSG00000134107 BHLHE40

ENSEMBL_homo_sapiens_GENE:ENSG00000134107.5 BHLHE40

HGNC:1046 BHLHE40

KEGG Gene (Homo sapiens):8553 BHLHE40

Monarch:8553 BHLHE40

NCBI Gene:8553 BHLHE40

OMIM:604256 BHLHE40

Reference Transcript

RefSeq:NM_003670.2 BHLHE40

Other Identifiers

11725983_at

16937024

201169_PM_s_at

201169_s_at

201170_PM_s_at

201170_s_at

2608731

2608732

2608733

2608734

2608736

2608738

2608740

2608743

2608744

2608745

2608746

2608747

2608749

2608751

40790_at

8077441

8553

A_14_P122372

A_14_P202182

A_24_P268676

GE53113

GO:0000122

GO:0000785

GO:0000978

GO:0000981

GO:0001227

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006351

GO:0006355

GO:0006357

GO:0007623

GO:0009952

GO:0016604

GO:0019904

GO:0030154

GO:0032922

GO:0042752

GO:0042803

GO:0043153

GO:0043226

GO:0043425

GO:0043426

GO:0043433

GO:0045892

GO:0046982

GO:0046983

GO:0048511

GO:0048856

GO:0050767

GO:0061629

GO:0070888

GO:0140110

GO:1990837

HMNXSV003055902

Hs.171825.0.S1_3p_a_at

ILMN_1768534

PH_hs_0010283

TC03000015.hg

g4503298_3p_a_at

Participates

as an output of

Expression of DEC1 (BHLHE40, BHLHB2) (Homo sapiens)

Cross References

RefSeq

NP_003661.1

OpenTargets

ENSG00000134107

HPA

ENSG00000134107-BHLHE40

GeneCards

O14503

Ensembl

ENSG00000134107, ENST00000256495, ENSP00000256495

PRO

O14503

Pharos - Targets

O14503

HMDB Protein

HMDBP01925

Interactors (73)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NB12 SMYD1	1	SMYD1 [nucleoplasm] (R-HSA-5688412)	0.83	8
UniProt:O94955 RHOBTB3	1	RHOBTB3 [trans-Golgi network membrane] (R-HSA-6813908)	0.781	7
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.728	11
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.718	6
UniProt:B7ZLI8 B7ZLI8			0.718	6
UniProt:Q16613 AANAT	1	AANAT [cytosol] (R-HSA-209813)	0.718	6
UniProt:Q08AM6 VAC14	3	VAC14 [Golgi membrane] (R-HSA-1806235) VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219)	0.718	6
UniProt:Q9GZZ1 NAA50			0.718	6
UniProt:P10606 COX5B	1	COX5B [mitochondrial inner membrane] (R-HSA-164307)	0.666	4
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481)	0.581	3
UniProt:Q3LI66 KRTAP6-2	1	KRTAP6-2 [cytosol] (R-HSA-6810261)	0.556	3
UniProt:Q3LI64 KRTAP6-1	1	KRTAP6-1 [cytosol] (R-HSA-6810298)	0.556	3
UniProt:Q8WU79 SMAP2			0.556	3
UniProt:Q5W5X9 TTC23			0.556	3
UniProt:Q15911-2 ZFHX3			0.556	3
UniProt:C9JG97 C9JG97			0.556	3
UniProt:Q6ZRY4 RBPS2			0.556	3
UniProt:P18545 PDE6G	2	PDE6G [photoreceptor disc membrane] (R-HSA-52449) PDE6G [plasma membrane] (R-HSA-4085973)	0.556	3
UniProt:Q03060-25 CREM			0.556	3
UniProt:A1A580 KRTAP23-1	1	KRTAP23-1 [cytosol] (R-HSA-6810252)	0.556	3
UniProt:Q86YR5-3 GPSM1			0.556	3
UniProt:Q9NX01 TXN4B			0.556	3
UniProt:Q99471 PFDN5	1	PFDN5 [cytosol] (R-HSA-379548)	0.556	3
UniProt:Q86U06 RBM23			0.556	3
UniProt:Q96CS7 PKHB2			0.556	3
UniProt:O94964-4 MTCL2			0.556	3
UniProt:Q70EL1-9 USP54			0.556	3
UniProt:Q15038 DAZP2			0.556	5
UniProt:Q9NWB1-5 RBFOX1			0.556	3
UniProt:Q86UY5 FAM83A	1	FAM83A [cytosol] (R-HSA-9851391)	0.556	6
UniProt:Q3SYF9 KRTAP19-7	1	KRTAP19-7 [cytosol] (R-HSA-6810305)	0.556	3
UniProt:Q9HC98-4 NEK6			0.556	3
UniProt:Q14106 TOB2			0.556	3
UniProt:Q3LI72 KRTAP19-5	1	KRTAP19-5 [cytosol] (R-HSA-6810300)	0.556	3
IntAct:EBI-16428938 CCSB ISOFORM ID			0.556	3
UniProt:Q9Y4B4 ARIP4			0.556	3
UniProt:Q86U06-2 RBM23			0.556	3
UniProt:P86480 PR20D			0.556	3
UniProt:Q8IUB9 KRTAP19-1	1	KRTAP19-1 [cytosol] (R-HSA-6810285)	0.556	3
UniProt:Q93062 RBPMS			0.556	3
IntAct:EBI-22317115 CCSB ORF ID			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q9BVI4 NOC4L	1	NOC4L [nucleoplasm] (R-HSA-6790616)	0.556	3
UniProt:O43189 PHF1	1	PHF1 [nucleoplasm] (R-HSA-5084105)	0.556	3
UniProt:Q8IUC2 KRTAP8-1	1	KRTAP8-1 [cytosol] (R-HSA-6810288)	0.556	3
UniProt:Q8IUG1 KRTAP1-3	1	KRTAP1-3 [cytosol] (R-HSA-6809866)	0.556	3
UniProt:Q14847-2 LASP1			0.556	3
UniProt:P19544-6 WT1			0.556	3
UniProt:Q8NEA9 GMCL2			0.556	3
UniProt:Q9H4E5 RHOJ	1	RHOJ [plasma membrane] (R-HSA-3006725)	0.556	3
UniProt:Q96A09 TET5B			0.556	3
UniProt:P78424 PO6F2			0.556	3
UniProt:Q96G42 KLD7B			0.556	3
UniProt:P54253 ATX1			0.556	3
UniProt:Q8TAP4-4 LMO3			0.556	3
UniProt:Q6NVV7 CDPF1			0.556	3
UniProt:Q71RC2-6 LARP4			0.556	3
UniProt:O95231 VENTX	1	VENTX [nucleoplasm] (R-HSA-8853887)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:Q01974 ROR2	2	ROR2 [plasma membrane] (R-HSA-197731) ROR2 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140729)	0.556	3
UniProt:O75553 DAB1	2	DAB1 [cytosol] (R-HSA-8855236) p-Y198,220,232-DAB1 [cytosol] (R-HSA-8855227)	0.556	3
UniProt:O75909 CCNK	1	CCNK [nucleoplasm] (R-HSA-6796619)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:P19793 RXRA	4	RXRA [cytosol] (R-HSA-9619757) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) RXRA [nucleoplasm] (R-HSA-381319)	0.556	4
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.556	3
IntAct:EBI-22404606 CCSB ORF ID			0.556	3
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:P0C206 REX			0.556	3
UniProt:O60248 SOX15			0.556	3
UniProt:Q13131 PRKAA1	3	p-T183-PRKAA1 [cytosol] (R-HSA-380964) PRKAA1 [cytosol] (R-HSA-380935) p-T183-PRKAA1 [nucleoplasm] (R-HSA-2151206)	0.556	3
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.553	2
UniProt:P03410 TAX			0.488	2

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