Expression of DEC1 (BHLHE40, BHLHB2)

Stable Identifier
R-HSA-879798
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of DEC1 (BHLHE40, BHLHB2)
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The DEC1 (BHLHE40, BHLHB2) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. The DEC1 gene contains E-box elements in its promoter which bind the phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) heterodimer and confer circadian rhythm on its expression.
Literature References
PubMed ID Title Journal Year
14672706 A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation

Kawamoto, T, Noshiro, M, Sato, F, Maemura, K, Takeda, N, Nagai, R, Iwata, T, Fujimoto, K, Furukawa, M, Miyazaki, K, Honma, S, Honma, K, Kato, Y

Biochem Biophys Res Commun 2004
15560782 Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1

Sato, F, Kawamoto, T, Fujimoto, K, Noshiro, M, Honda, KK, Honma, S, Honma, K, Kato, Y

Eur J Biochem 2004
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
BHLHE40 dimer [nucleoplasm] (Homo sapiens)
Positively by
Regulator
p-S90-BMAL1:p-T451,T461-CLOCK:BHLHE40 gene [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Dec1 (Bhlhe40, Bhlhb2) (Mus musculus)
Authored
May, B  (2010-06-18)
Reviewed
D'Eustachio, P  (2009-05-27)
Albrecht, U  (2010-06-23)
Kay, SA  (2010-06-23)
Hirota, T  (2010-06-23)
Delaunay, F  (2010-06-23)
Albrecht, U  (2025-03-07)
Created
May, B  (2010-06-23)
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