Reactome | NR3C1 [nucleoplasm]

NR3C1 [nucleoplasm]

Stable Identifier

R-HSA-879837

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Glucocorticoid receptor, GCR_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of intracellular receptors (Homo sapiens)
        
        SUMOylation of NR3C1 (GR) with SUMO1 (Homo sapiens)
        
        NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
        
        NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
        
        NR3C1 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by PTK6 (Homo sapiens)
    - PTK6 Expression (Homo sapiens)
      - EPAS1 (HIF2A) and activated NR3C1 (GCR) bind PTK6 gene (Homo sapiens)
        
        NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
        
        NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
        
        NR3C1 [nucleoplasm] (Homo sapiens)
        
        PTK6 Gene:EPAS1:NR3C1:Glucocorticoid ligand:PELP1 [nucleoplasm] (Homo sapiens)
        
        NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
        
        NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
        
        NR3C1 [nucleoplasm] (Homo sapiens)
      - HIF1A,EPAS1 promote PTK6 gene expression (Homo sapiens)
        
        NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
        
        NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
        
        NR3C1 [nucleoplasm] (Homo sapiens)
        
        PTK6 Gene:EPAS1:NR3C1:Glucocorticoid ligand:PELP1 [nucleoplasm] (Homo sapiens)
        
        NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
        
        NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm] (Homo sapiens)
        
        NR3C1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04150 NR3C1

Gene Names

NR3C1, GRL

Chain

chain:1-777

Reference Genes

BioGPS Gene:2908 NR3C1

COSMIC (genes):NR3C1 NR3C1

CTD Gene:2908 NR3C1

dbSNP Gene:2908 NR3C1

ENSEMBL:ENSG00000113580 NR3C1

ENSEMBL_homo_sapiens_GENE:ENSG00000113580.15 NR3C1

HGNC:7978 NR3C1

KEGG Gene (Homo sapiens):2908 NR3C1

Monarch:2908 NR3C1

NCBI Gene:2908 NR3C1

OMIM:138040 NR3C1

UCSC:P04150 NR3C1

Reference Transcript

Other Identifiers

1102_s_at

11735194_a_at

11736504_a_at

11741227_a_at

11742190_a_at

11742425_a_at

11743737_a_at

11743738_a_at

11743739_a_at

11751289_a_at

11755240_s_at

17001100

201865_3p_x_at

201865_PM_x_at

201865_x_at

201866_PM_s_at

201866_s_at

211671_PM_s_at

211671_s_at

216321_PM_s_at

216321_s_at

2879322

2879323

2879324

2879325

2879326

2879327

2879336

2879338

2879339

2879342

2879346

2879347

2879373

2879374

2879375

2879378

2879379

2879380

2879381

2879382

2879383

2879384

2879385

2879386

2879387

2879398

2879400

2908

36690_at

3672865

706_at

8114814

A_23_P214059

A_24_P214754

A_33_P3216297

A_33_P3767927

GE57805

GO:0000122

GO:0000785

GO:0000977

GO:0000978

GO:0000981

GO:0001046

GO:0001227

GO:0001228

GO:0003677

GO:0003700

GO:0003723

GO:0004879

GO:0004883

GO:0005496

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005759

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005975

GO:0006111

GO:0006325

GO:0006351

GO:0006355

GO:0006357

GO:0006629

GO:0006915

GO:0006954

GO:0007049

GO:0007059

GO:0007165

GO:0008211

GO:0008270

GO:0008289

GO:0010467

GO:0012501

GO:0014004

GO:0016020

GO:0016607

GO:0017025

GO:0019901

GO:0022414

GO:0023052

GO:0030154

GO:0030325

GO:0030518

GO:0031946

GO:0032991

GO:0034056

GO:0035249

GO:0042711

GO:0042802

GO:0042921

GO:0043226

GO:0043402

GO:0043525

GO:0043565

GO:0045202

GO:0045892

GO:0045944

GO:0046872

GO:0048708

GO:0048856

GO:0051301

GO:0051647

GO:0051879

GO:0060089

GO:0060603

GO:0061744

GO:0071383

GO:0071385

GO:0071549

GO:0071560

GO:0140110

GO:0150076

GO:1902895

GO:1990239

GO:1990837

HMNXSV003012343

HMNXSV003022467

Hs.75772.0.S1_3p_a_at

Hs.75772.1.S1_3p_a_at

ILMN_1668525

ILMN_1812384

ILMN_2389347

M10901_at

PH_hs_0026745

TC05001887.hg

g4504132_3p_a_at

g458656_3p_s_at

Participates

as a component of

Other forms of this molecule

SUMO1-K277,K293-NR3C1 [nucleoplasm]

NR3C1 [cytosol]

Inferred To

Ghost homologue of NR3C1 [nucleoplasm] (Plasmodium falciparum)

nr3c1 [nucleoplasm] (Danio rerio)

nr3c1 [nucleoplasm] (Xenopus tropicalis)

knrl [nucleoplasm] (Drosophila melanogaster)

Nr3c1 [nucleoplasm] (Mus musculus)

Nr3c1 [nucleoplasm] (Rattus norvegicus)

ERR [nucleoplasm] (Drosophila melanogaster)

kni [nucleoplasm] (Drosophila melanogaster)

NR3C1-1 [nucleoplasm] (Gallus gallus)

NR3C1 [nucleoplasm] (Bos taurus)

NR3C1 [nucleoplasm] (Canis familiaris)

NR3C1 [nucleoplasm] (Sus scrofa)

Homologues of NR3C1-1 [nucleoplasm] (Drosophila melanogaster)

eg [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001191192.1, NP_001018085.1, XP_016864887.1, NP_001018086.1, NP_001191189.1, NP_001191193.1, NP_001018661.1, XP_016864886.1, NP_001018087.1, XP_005268476.1, NP_001019265.1, XP_005268477.1, NP_001191190.1, NP_001191187.1, NP_001191191.1, NP_000167.1, XP_005268479.1, XP_005268480.1, NP_001191188.1, NP_001018084.1

ZINC - World Drugs

GCR_HUMAN

Guide to Pharmacology - Targets

625

OpenTargets

ENSG00000113580

ZINC - FDA approved

GCR_HUMAN

ZINC - Substances

GCR_HUMAN

ZINC target

P04150

ZINC - Biogenic

GCR_HUMAN

PRO

P04150

PDB

5G3J, 6YMO, 7PRX, 5E6B, 6BQU, 5NFT, 8VKZ, 4UDC, 5CBX, 3CLD, 6X6D, 6EL9, 1P93, 6YO8, 5E6C, 5CBY, 4HN5, 3H52, 5UC1, 6EL6, 5EMC, 6YOS, 5E6D, 4P6X, 3K22, 7KW7, 7KRJ, 5E69, 3E7C, 5VA0, 5EMP, 4HN6, 5CBZ, 6X6E, 4MDD, 1NHZ, 6DXK, 4CSJ, 5EMQ, 4UDD, 8FFW, 5G5W, 7PRW, 5VA7, 4P6W, 8FFV, 1M2Z, 5NFP, 4LSJ, 3K23, 6CFN, 5CC1, 7PRV, 5UC3, 8A9G, 5E6A, 6EL7, 3BQD

ZINC - Investigational

GCR_HUMAN

ZINC - Metabolites

GCR_HUMAN

GeneCards

P04150

HPA

ENSG00000113580-NR3C1

Ensembl

ENSP00000343205, ENSP00000377979, ENSP00000427672, ENST00000503201, ENSG00000113580, ENST00000394464, ENSP00000231509, ENSP00000387672, ENSP00000405282, ENST00000504572, ENST00000394466, ENSP00000377977, ENST00000231509, ENST00000343796, ENST00000424646, ENST00000415690, ENSP00000422518

Pharos - Targets

P04150

Orphanet

16572

ZINC - Predictions - Purchasable

GCR_HUMAN

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.775	8
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.643	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.635	3
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.611	5
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.61	5
UniProt:Q13451 FKBP5	2	FKBP5 [cytosol] (R-HSA-5618096) FKBP5 [nucleoplasm] (R-HSA-8939165)	0.527	2
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.463	3