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NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm]
Stable Identifier
R-HSA-879850
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Glucocorticoid receptor:Glucocorticoid ligand complex dimer, GR:Glucocorticoid ligand dimer
Locations in the PathwayBrowser
Expand all
Circadian Clock (Homo sapiens)
Expression of PERIOD-2 (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)
FOXO1 and NR3C1 bind TRIM63 gene promoter (Homo sapiens)
FOXO1:NR3C1:(ALDO,11DCORST,CORST,CORT):TRIM63 gene [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
TRIM63 gene expression is stimulated by FOXO1 and FOXO3 (Homo sapiens)
FOXO1:NR3C1:(ALDO,11DCORST,CORST,CORT):TRIM63 gene [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
Transcriptional Regulation by NPAS4 (Homo sapiens)
Regulation of NPAS4 gene expression (Homo sapiens)
Regulation of NPAS4 gene transcription (Homo sapiens)
Activated glucocorticoid receptor binds NPAS4 gene promoter (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer:NPAS4 gene [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
Activated glucocorticoid receptor represses NPAS4 gene transcription (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer:NPAS4 gene [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
DEXA:NR3C1 complex binds RUNX2 gene proximal promoter (Homo sapiens)
Glucocorticoid ligand:NR3C1:RUNX2 gene [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 (Homo sapiens)
Glucocorticoid ligand:NR3C1:RUNX2 gene [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
SUMOylation of NR3C1 (GR) with SUMO1 (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Expression (Homo sapiens)
EPAS1 (HIF2A) and activated NR3C1 (GCR) bind PTK6 gene (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
PTK6 Gene:EPAS1:NR3C1:Glucocorticoid ligand:PELP1 [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
HIF1A,EPAS1 promote PTK6 gene expression (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
PTK6 Gene:EPAS1:NR3C1:Glucocorticoid ligand:PELP1 [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm] (Homo sapiens)
Participants
components
x 2
NR3C1:(ALDO,11DCORST,CORST,CORT) [nucleoplasm]
(Homo sapiens)
Participates
as an input of
SUMOylation of NR3C1 (GR) with SUMO1 (Homo sapiens)
FOXO1 and NR3C1 bind TRIM63 gene promoter (Homo sapiens)
DEXA:NR3C1 complex binds RUNX2 gene proximal promoter (Homo sapiens)
Activated glucocorticoid receptor binds NPAS4 gene promoter (Homo sapiens)
EPAS1 (HIF2A) and activated NR3C1 (GCR) bind PTK6 gene (Homo sapiens)
as a component of
FOXO1:NR3C1:(ALDO,11DCORST,CORST,CORT):TRIM63 gene [nucleoplasm] (Homo sapiens)
Glucocorticoid ligand:NR3C1:RUNX2 gene [nucleoplasm] (Homo sapiens)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer:NPAS4 gene [nucleoplasm] (Homo sapiens)
PTK6 Gene:EPAS1:NR3C1:Glucocorticoid ligand:PELP1 [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
Expression of PERIOD-2
(Homo sapiens)
Inferred To
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm]
(Bos taurus)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm]
(Canis familiaris)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm]
(Danio rerio)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm]
(Drosophila melanogaster)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm]
(Gallus gallus)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm]
(Mus musculus)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm]
(Rattus norvegicus)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm]
(Sus scrofa)
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm]
(Xenopus tropicalis)
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