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Gastrin-CREB signalling pathway via PKC and MAPK
Stable Identifier
R-HSA-881907
DOI
10.3180/REACT_120966.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)
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Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17.Gastrin gene expression is upregulated in both a number of pre-malignant conditions and in established cancer through a variety of mechanisms. Depending on the tissue where it is expressed and the level of expression, differential processing of the polypeptide product leads to the production of different biologically active peptides. In turn, acting through the classical gastrin cholecystokinin B receptor CCK-BR, its isoforms and alternative receptors, these peptides trigger signalling pathways which influence the expression of downstream genes that affect cell survival, angiogenesis and invasion (Wank 1995, de Weerth et al. 1999, Grabowska & Watson 2007)
Literature References
PubMed ID
Title
Journal
Year
17698287
Role of gastrin peptides in carcinogenesis
Watson, SA
,
Grabowska, AM
Cancer Lett
2007
10413847
[Receptors for cholecystokinin and gastrin]
Bläker, M
,
de Weerth, A
,
von Schrenck, T
Z Gastroenterol
1999
7491953
Cholecystokinin receptors
Wank, SA
Am J Physiol
1995
Participants
Events
Gastrin binds to CCK-B receptor
(Homo sapiens)
EGFR Transactivation by Gastrin
(Homo sapiens)
ERK1/2/5 activate RSK1/2/3
(Homo sapiens)
RSK1/2/3 phosphorylates CREB at Serine 119
(Homo sapiens)
Participates
as an event of
G alpha (q) signalling events (Homo sapiens)
Orthologous Events
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Gastrin-CREB signalling pathway via PKC and MAPK (Danio rerio)
Gastrin-CREB signalling pathway via PKC and MAPK (Dictyostelium discoideum)
Gastrin-CREB signalling pathway via PKC and MAPK (Drosophila melanogaster)
Gastrin-CREB signalling pathway via PKC and MAPK (Gallus gallus)
Gastrin-CREB signalling pathway via PKC and MAPK (Mus musculus)
Gastrin-CREB signalling pathway via PKC and MAPK (Rattus norvegicus)
Gastrin-CREB signalling pathway via PKC and MAPK (Saccharomyces cerevisiae)
Gastrin-CREB signalling pathway via PKC and MAPK (Schizosaccharomyces pombe)
Gastrin-CREB signalling pathway via PKC and MAPK (Sus scrofa)
Gastrin-CREB signalling pathway via PKC and MAPK (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000477
Authored
Tripathi, S (2012-04-04)
Jassal, B (2012-04-04)
Reviewed
D'Eustachio, P (2012-04-23)
Created
Jassal, B (2010-06-28)
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