ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane

Stable Identifier
R-HSA-8847638
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane
ReviewStatus
5/5
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ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane
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NSF-mediated ATP hydrolysis promotes disassembly of the cis-SNARE complex, allowing the SNAREs to be reused in subsequent rounds of vesicle fusion (reviewed in Sudhof and Rothman, 2009; Hong and Lev, 2014).
Literature References
PubMed ID Title Journal Year
24119662 Tethering the assembly of SNARE complexes

Hong, W, Lev, S

Trends Cell Biol. 2014
19164740 Membrane fusion: grappling with SNARE and SM proteins

Südhof, TC, Rothman, JE

Science 2009
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Output
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as an event of
Catalyst Activity

ATP hydrolysis activity of STX5:PalmC-YKT6:BET1L:GOSR1:NSF hexamer:3xSNAPs [Golgi membrane]

Physical Entity
STX5:PalmC-YKT6:BET1L:GOSR1:NSF hexamer:3xSNAPs [Golgi membrane] (Homo sapiens)
Activity
ATP hydrolysis activity (GO:0016887)
Orthologous Events
ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Bos taurus)
ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Canis familiaris)
ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Dictyostelium discoideum)
ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Gallus gallus)
ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Mus musculus)
ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Rattus norvegicus)
ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Saccharomyces cerevisiae)
ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Schizosaccharomyces pombe)
ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Sus scrofa)
Authored
Rothfels, K  (2015-11-09)
Reviewed
Gillespie, ME  (2016-02-02)
Created
Rothfels, K  (2015-12-02)
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