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CASP14(6-146) [cytosol]
Stable Identifier
R-HSA-8847667
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Caspase-14 p17 subunit, CASPE_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Developmental Cell Lineages (Homo sapiens)
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin (Homo sapiens)
Keratinocyte of granulosum layer differentiates into corneocyte of corneum layer in interfollicular epidermis (Homo sapiens)
corneocyte (Homo sapiens)
CASP14(6-146) [cytosol] (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
CASP14 cleaves filaggrin (Homo sapiens)
CASP14 [cytosol] (Homo sapiens)
CASP14(6-146) [cytosol] (Homo sapiens)
Cytoplasmic proteases cleave Profilaggrin producing Filaggrin (Homo sapiens)
Cytoplasmic profilaggrin processing proteases [cytosol] (Homo sapiens)
CASP14 [cytosol] (Homo sapiens)
CASP14(6-146) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P31944 CASP14
Gene Names
CASP14
Chain
chain:1-178, propeptide:1-5, chain:6-146, propeptide:147-152, chain:153-242, chain:179-242
Reference Genes
BioGPS Gene:23581 CASP14
COSMIC (genes):CASP14 CASP14
CTD Gene:23581 CASP14
dbSNP Gene:23581 CASP14
ENSEMBL:ENSG00000105141 CASP14
HGNC:1502 CASP14
Monarch:23581 CASP14
NCBI Gene:23581 CASP14
OMIM:605848 CASP14
UCSC:P31944 CASP14
Reference Transcript
RefSeq:NM_012114.2 CASP14
Other Identifiers
11715288_s_at
11759142_at
16859090
231722_PM_at
231722_at
23581
3822977
3822981
3822982
3822984
3822985
3822986
3822987
3822988
3822989
3822990
3822992
3822993
3822995
3822997
8026398
A_14_P107583
A_23_P90407
GE81754
GO:0001533
GO:0003824
GO:0004197
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0006508
GO:0008233
GO:0008234
GO:0008544
GO:0012501
GO:0016787
GO:0030154
GO:0031424
GO:0043226
GO:0043525
GO:0045095
GO:0048856
GO:0070268
GO:0140096
HMNXSV003027016
Hs.248226.0.S1_3p_at
ILMN_1739513
PH_hs_0013191
TC19000266.hg
Participates
as a protein marker of
corneocyte (Homo sapiens)
as a component of
CASP14 [cytosol] (Homo sapiens)
Other forms of this molecule
CASP14(153-242) [cytosol]
Inferred To
Casp14 [cytosol]
(Mus musculus)
Casp14 [cytosol]
(Rattus norvegicus)
CASP14 [cytosol]
(Bos taurus)
CASP14 [cytosol]
(Canis familiaris)
Cross References
Guide to Pharmacology - Targets
1627
ENSEMBL
ENSP00000393417
,
ENST00000427043
OpenTargets
ENSG00000105141
HPA
ENSG00000105141-CASP14
ZINC - Substances
CASPE_HUMAN
ZINC target
P31944
PRO
P31944
Pharos - Targets
P31944
GlyGen
P31944
ZINC - Predictions - Purchasable
CASPE_HUMAN
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
10
UniProt:Q9Y324 FCF1
1
FCF1 [nucleoplasm]
(R-HSA-6790672)
0.527
2
UniProt:Q15915 ZIC1
1
ZIC1 [nucleoplasm]
(R-HSA-9731648)
0.527
2
UniProt:P07602 PSAP
11
PSAP(326-340) [extracellular region]
(R-HSA-5336179)
PSAP(?-?) [extracellular region]
(R-HSA-5336190)
PSAP(17-524) [azurophil granule membrane]
(R-HSA-6799212)
PSAP(17-524) [plasma membrane]
(R-HSA-6806262)
PSAP(195-273) [lysosomal lumen]
(R-HSA-9840336)
PSAP [lysosomal lumen]
(R-HSA-9840325)
PSAP(60-142) [lysosomal lumen]
(R-HSA-351333)
PSAP(311-391) [lysosomal membrane]
(R-HSA-1605602)
PSAP(405-486) [lysosomal lumen]
(R-HSA-9840328)
PSAP(311-391) [lysosomal lumen]
(R-HSA-9851355)
PSAP(60-142) [extracellular region]
(R-HSA-351338)
0.471
3
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