Reactome | CASP14(153-242) [cytosol]

CASP14(153-242) [cytosol]

Stable Identifier

R-HSA-8847687

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Caspase-14 p10 subunit, CASPE_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P31944 CASP14

Gene Names

CASP14

Chain

chain:1-178, propeptide:1-5, chain:6-146, propeptide:147-152, chain:153-242, chain:179-242

Reference Genes

BioGPS Gene:23581 CASP14

COSMIC (genes):CASP14 CASP14

CTD Gene:23581 CASP14

dbSNP Gene:23581 CASP14

ENSEMBL:ENSG00000105141 CASP14

ENSEMBL_homo_sapiens_GENE:ENSG00000105141.6 CASP14

HGNC:1502 CASP14

KEGG Gene (Homo sapiens):23581 CASP14

Monarch:23581 CASP14

NCBI Gene:23581 CASP14

OMIM:605848 CASP14

UCSC:P31944 CASP14

Reference Transcript

RefSeq:NM_012114.2 CASP14

Other Identifiers

11715288_s_at

11759142_at

16859090

231722_PM_at

231722_at

23581

3822977

3822981

3822982

3822984

3822985

3822986

3822988

3822989

3822990

3822992

3822993

3822995

3822997

8026398

A_14_P107583

A_23_P90407

GE81754

GO:0001533

GO:0003824

GO:0004197

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005856

GO:0005886

GO:0006508

GO:0008233

GO:0008234

GO:0008544

GO:0012501

GO:0016787

GO:0030154

GO:0031424

GO:0043226

GO:0045095

GO:0048856

GO:0070268

GO:0140096

HMNXSV003027016

Hs.248226.0.S1_3p_at

ILMN_1739513

PH_hs_0013191

TC19000266.hg

Participates

as a protein marker of

corneocyte (Homo sapiens)

as a component of

CASP14 [cytosol] (Homo sapiens)

Other forms of this molecule

CASP14(6-146) [cytosol]

Inferred To

Casp14 [cytosol] (Mus musculus)

Casp14 [cytosol] (Rattus norvegicus)

CASP14 [cytosol] (Bos taurus)

CASP14 [cytosol] (Canis familiaris)

Cross References

RefSeq

NP_036246.1

Guide to Pharmacology - Targets

1627

OpenTargets

ENSG00000105141

GeneCards

P31944

ZINC - Substances

CASPE_HUMAN

HPA

ENSG00000105141-CASP14

Ensembl

ENSG00000105141, ENST00000427043, ENSP00000393417

ZINC target

P31944

PRO

P31944

Pharos - Targets

P31944

ZINC - Predictions - Purchasable

CASPE_HUMAN

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	10
UniProt:Q15915 ZIC1	1	ZIC1 [nucleoplasm] (R-HSA-9731648)	0.527	2
UniProt:Q9Y324 FCF1	1	FCF1 [nucleoplasm] (R-HSA-6790672)	0.527	2
UniProt:P07602 PSAP	11	PSAP(60-142) [extracellular region] (R-HSA-351338) PSAP(17-524) [plasma membrane] (R-HSA-6806262) PSAP(17-524) [azurophil granule membrane] (R-HSA-6799212) PSAP(311-391) [lysosomal lumen] (R-HSA-9851355) PSAP(405-486) [lysosomal lumen] (R-HSA-9840328) PSAP(311-391) [lysosomal membrane] (R-HSA-1605602) PSAP(60-142) [lysosomal lumen] (R-HSA-351333) PSAP [lysosomal lumen] (R-HSA-9840325) PSAP(195-273) [lysosomal lumen] (R-HSA-9840336) PSAP(?-?) [extracellular region] (R-HSA-5336190) PSAP(326-340) [extracellular region] (R-HSA-5336179)	0.471	3

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