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PTK6 [cytosol]
Stable Identifier
R-HSA-8848000
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein-tyrosine kinase 6, Breast tumor kinase, Tyrosine-protein kinase BRK, BRK
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
ERBB2 Activates PTK6 Signaling (Homo sapiens)
Activated ERBB2 binds PTK6 (BRK) (Homo sapiens)
PTK6 [cytosol] (Homo sapiens)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Homo sapiens)
PTK6 [cytosol] (Homo sapiens)
ERBB2 promotes PTK6 autophosphorylation (Homo sapiens)
PTK6 [cytosol] (Homo sapiens)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Homo sapiens)
PTK6 [cytosol] (Homo sapiens)
PTK6 Down-Regulation (Homo sapiens)
PTPN1 dephosphorylates PTK6 (Homo sapiens)
PTK6 [cytosol] (Homo sapiens)
PTK6 Expression (Homo sapiens)
HIF1A,EPAS1 promote PTK6 gene expression (Homo sapiens)
PTK6 [cytosol] (Homo sapiens)
PTK6 promotes HIF1A stabilization (Homo sapiens)
LINC01139 facilitates PTK6 autophosphorylation (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB:LINC01139:PTK6:LRRK2 [plasma membrane] (Homo sapiens)
PTK6 [cytosol] (Homo sapiens)
PTK6 [cytosol] (Homo sapiens)
Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB:LINC01139:PTK6:LRRK2 [plasma membrane] (Homo sapiens)
PTK6 [cytosol] (Homo sapiens)
PTK6 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
ERBB2 Activates PTK6 Signaling (Homo sapiens)
Activated ERBB2 binds PTK6 (BRK) (Homo sapiens)
PTK6 [cytosol] (Homo sapiens)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Homo sapiens)
PTK6 [cytosol] (Homo sapiens)
ERBB2 promotes PTK6 autophosphorylation (Homo sapiens)
PTK6 [cytosol] (Homo sapiens)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Homo sapiens)
PTK6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13882 PTK6
Gene Names
PTK6, BRK
Chain
chain:1-451
Reference Genes
BioGPS Gene:5753 PTK6
COSMIC (genes):PTK6 PTK6
CTD Gene:5753 PTK6
dbSNP Gene:5753 PTK6
ENSEMBL:ENSG00000101213 PTK6
HGNC:9617 PTK6
KEGG:hsa:5753 PTK6
Monarch:5753 PTK6
NCBI Gene:5753 PTK6
OMIM:602004 PTK6
UCSC:Q13882 PTK6
Reference Transcript
RefSeq:NM_001256358.1 PTK6
RefSeq:NM_005975.3 PTK6
Other Identifiers
11748835_a_at
11755228_a_at
1208_at
1553114_3p_a_at
1553114_PM_a_at
1553114_a_at
16921268
206482_PM_at
206482_at
33559_at
3913927
3913928
3913929
3913931
3913932
3913933
3913936
3913937
3913938
3913939
3913941
3913942
5753
8067662
A_23_P56978
GE484877
GE80189
GO:0001726
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005102
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0007169
GO:0007260
GO:0010976
GO:0016020
GO:0016477
GO:0016604
GO:0016740
GO:0030154
GO:0038128
GO:0042802
GO:0042995
GO:0043226
GO:0045087
GO:0045740
GO:0045742
GO:0045787
GO:0045926
GO:0046427
GO:0046777
GO:0048870
GO:0060575
GO:0061099
GO:0071300
GO:0098542
GO:0140096
HMNXSV003006584
Hs2.51133.1.S1_3p_x_at
ILMN_1764508
ILMN_2075800
PH_hs_0003525
TC20001033.hg
X78549_at
g5174646_3p_at
Participates
as an output of
PTPN1 dephosphorylates PTK6 (Homo sapiens)
HIF1A,EPAS1 promote PTK6 gene expression (Homo sapiens)
as an input of
Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 (Homo sapiens)
Activated ERBB2 binds PTK6 (BRK) (Homo sapiens)
as a component of
HBEGF:EGFR:p-Y525-GPNMB:LINC01139:PTK6:LRRK2 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y342-PTK6 [cytosol]
p-Y342-PTK6 [nucleoplasm]
p-Y351-PTK6 [cytosol]
p-Y342,Y447-PTK6 [cytosol]
Inferred To
Ptk6 [cytosol]
(Rattus norvegicus)
Ghost homologue of PTK6 [cytosol]
(Canis familiaris)
Ghost homologue of PTK6 [cytosol]
(Drosophila melanogaster)
Ghost homologue of PTK6 [cytosol]
(Gallus gallus)
Homologues of PTK6 [cytosol]
(Caenorhabditis elegans)
PTK6 [cytosol]
(Bos taurus)
PTK6 [cytosol]
(Caenorhabditis elegans)
PTK6 [cytosol]
(Danio rerio)
PTK6 [cytosol]
(Mus musculus)
PTK6 [cytosol]
(Sus scrofa)
PTK6 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_005966.1
,
NP_001243287.1
ZINC - World Drugs
PTK6_HUMAN
Guide to Pharmacology - Targets
2182
OpenTargets
ENSG00000101213
ENSEMBL
ENSP00000442460
,
ENSP00000217185
,
ENST00000542869
,
ENST00000217185
ZINC - FDA approved
PTK6_HUMAN
ZINC - Substances
PTK6_HUMAN
ZINC - Biogenic
PTK6_HUMAN
ZINC target
Q13882
PRO
Q13882
PDB
1RJA
,
5D7V
,
5DA3
,
6CZ2
,
2KGT
,
5H2U
,
6CZ4
,
6CZ3
ZINC - Investigational
PTK6_HUMAN
HPA
ENSG00000101213-PTK6
Pharos - Targets
Q13882
ZINC - Predictions - Purchasable
PTK6_HUMAN
HMDB Protein
HMDBP01216
Interactors (31)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5JST6 EFHC2
0.781
7
UniProt:O00471 EXOC5
2
EXOC5 [cytosol]
(R-HSA-265045)
EXOC5 [cytosol]
(R-HSA-5623383)
0.718
6
UniProt:Q13882 PTK6
5
PTK6 [cytosol]
(R-HSA-8848000)
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
0.713
3
UniProt:Q92841 DDX17
2
monoSUMO1-K50-DDX17 [nucleoplasm]
(R-HSA-3900104)
DDX17 [nucleoplasm]
(R-HSA-3900090)
0.666
4
UniProt:Q5VWX1 KHDRBS2
2
KHDRBS2 [nucleoplasm]
(R-HSA-8849028)
p-Y-KHDRBS2 [nucleoplasm]
(R-HSA-8849031)
0.666
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
4
UniProt:O14526 FCHO1
1
FCHO1 [cytosol]
(R-HSA-8862257)
0.666
4
UniProt:P23246 SFPQ
3
SFPQ [nucleoplasm]
(R-HSA-3900138)
p-Y-SFPQ [nucleoplasm]
(R-HSA-8849461)
SFPQ [cytosol]
(R-HSA-9635505)
0.632
5
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.628
4
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.564
3
UniProt:O00401 WASL
4
p-Y256-WASL [cytosol]
(R-HSA-2197672)
N-WASP [cytosol]
(R-HSA-201873)
WASL [plasma membrane]
(R-HSA-203010)
WASL [endocytic vesicle membrane]
(R-HSA-535012)
0.556
3
UniProt:Q9NQX0 PRDM6
0.556
3
IntAct:EBI-10171584 80125
0.556
3
UniProt:Q08043 ACTN3
1
ACTN3 [cytosol]
(R-HSA-390565)
0.556
3
UniProt:P78337 PITX1
0.556
3
UniProt:Q13239-3 Q132393
0.556
3
UniProt:Q3KP44 ANR55
0.556
3
UniProt:Q13191 CBLB
1
CBLB [cytosol]
(R-HSA-976009)
0.556
3
UniProt:Q9UKT9 IKZF3
0.556
3
UniProt:Q9BYN7 ZN341
0.556
3
UniProt:O14770-4 MEIS2
0.556
3
UniProt:Q5T5P2-6 KIAA1217
0.556
3
UniProt:Q8N9I9 DTX3
0.556
3
UniProt:Q8TDC0 MYOZ3
0.556
3
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.556
3
UniProt:Q13064 MKRN3
0.556
3
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.527
3
UniProt:P50991 CCT4
1
CCT4 [cytosol]
(R-HSA-390458)
0.527
3
UniProt:P50990 CCT8
5
CCT8 [secretory granule lumen]
(R-HSA-6801035)
CCT8 [extracellular region]
(R-HSA-6806238)
CCT8 [azurophil granule lumen]
(R-HSA-6799369)
CCT8 [ficolin-1-rich granule lumen]
(R-HSA-6800894)
CCT8 [cytosol]
(R-HSA-390449)
0.527
3
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.527
3
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.499
4
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