Reactome | ERBB2 promotes PTK6 autophosphorylation

ERBB2 promotes PTK6 autophosphorylation

Stable Identifier

R-HSA-8848005

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Binding of PTK6 (BRK) to activated ERBB2 receptor stimulates autophosphorylation of PTK6 on tyrosine residue Y342 (Xiang et al. 2008, Peng et al. 2015). Autophosphorylation at Y342 significantly increases catalytic activity of PTK6 (Qiu and Miller 2002).

Literature References

PubMed ID	Title	Journal	Year
18719096	Brk is coamplified with ErbB2 to promote proliferation in breast cancer Muthuswamy, SK, Xiang, B, Lakshmi, B, Yu, M, Miller, WT, Krasnitz, A, Hicks, J, Qiu, H, Chatti, K	Proc. Natl. Acad. Sci. U.S.A.	2008