ACAT2 condenses 2 Ac-CoA to form ACA-CoA

Stable Identifier
R-HSA-8848215
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Three human enzymes can utilise ketone bodies for energy production. Two mitochondrial enzymes function in ketolysis whereas a cytosolic enzyme is implicated in cytosolic cholesterol biosynthesis. Cytosolic acetyl-CoA acetyltransferase tetramer (ACAT2 tetramer) (Song et al. 1994) catalyses the condensation of two acetyl-CoA (Ac-CoA) molecules to form acetoacetyl-CoA (ACA-CoA). This is the first step in the biosynthesis of cholesterol (Fukao et al. 1997).

Literature References
PubMed ID Title Journal Year
9380443 Enzymes of ketone body utilization in human tissues: protein and messenger RNA levels of succinyl-coenzyme A (CoA):3-ketoacid CoA transferase and mitochondrial and cytosolic acetoacetyl-CoA thiolases

Sukegawa, K, Orii, T, Mitchell, GA, Kondo, N, Yamaguchi, S, Fukao, T, Song, XQ

Pediatr. Res. 1997
7911016 Molecular cloning and nucleotide sequence of complementary DNA for human hepatic cytosolic acetoacetyl-coenzyme A thiolase

Hashimoto, T, Orii, T, Yamaguchi, S, Fukao, T, Miyazawa, S, Song, XQ

Biochem. Biophys. Res. Commun. 1994
Participants
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Participates
Catalyst Activity

acetyl-CoA C-acetyltransferase activity of ACAT2 tetramer [cytosol]

Orthologous Events
Cross References
Rhea
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