Reactome | PNPLA5 [cytosol]

PNPLA5 [cytosol]

Stable Identifier

R-HSA-8848346

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Patatin-like phospholipase domain-containing protein 5, GS2-like

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
17603008	A comparative study of human GS2, its paralogues, and its rat orthologue Gao, JG, Simon, M	Biochem. Biophys. Res. Commun.	2007

External Reference Information

External Reference

UniProt:Q7Z6Z6 PNPLA5

Gene Names

PNPLA5, GS2L

Chain

chain:1-429

Reference Genes

BioGPS Gene:150379 PNPLA5

COSMIC (genes):PNPLA5 PNPLA5

CTD Gene:150379 PNPLA5

dbSNP Gene:150379 PNPLA5

ENSEMBL:ENSG00000100341 PNPLA5

HGNC:24888 PNPLA5

KEGG:hsa:150379 PNPLA5

Monarch:150379 PNPLA5

NCBI Entrez Gene:150379 PNPLA5

OMIM:611589 PNPLA5

UCSC:Q7Z6Z6 PNPLA5

Reference Transcript

Other Identifiers

11737352_a_at

150379

16935892

233597_PM_at

233597_at

3963139

3963140

3963141

3963142

3963143

3963144

3963145

3963146

3963149

3963150

3963151

3963152

3963153

3963154

3963155

3963156

3963157

8076655

A_23_P377312

A_33_P3559060

GE812881

GO:0003824

GO:0004806

GO:0005515

GO:0005737

GO:0005811

GO:0005829

GO:0006629

GO:0016020

GO:0016042

GO:0016787

GO:0019433

GO:0043226

GO:0055088

HMNXSV003032732

Hs.248086.0.S1_3p_at

ILMN_1771364

PH_hs_0032308

TC22000865.hg

Inferred To

Homologues of PNPLA5 [cytosol] (Caenorhabditis elegans)

Homologues of PNPLA5 [cytosol] (Drosophila melanogaster)

PNPLA5 [cytosol] (Caenorhabditis elegans)

PNPLA5 [cytosol] (Canis familiaris)

PNPLA5 [cytosol] (Gallus gallus)

PNPLA5 [cytosol] (Plasmodium falciparum)

bmm [cytosol] (Drosophila melanogaster)

atgl-1 [cytosol] (Caenorhabditis elegans)

pnpla3 [cytosol] (Danio rerio)

pnpla3 [cytosol] (Xenopus tropicalis)

Pnpla5 [cytosol] (Mus musculus)

Pnpla5 [cytosol] (Rattus norvegicus)

dob [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_620169.1, NP_001171146.1

ENSEMBL

ENSP00000216177, ENST00000381198, ENSG00000100341, ENST00000216177, ENSP00000370595

OpenTargets

ENSG00000100341

GeneCards

PNPLA5

HPA

ENSG00000100341-PNPLA5

PRO

Q7Z6Z6

Pharos - Targets

Q7Z6Z6

HMDB Protein

HMDBP12139

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92624 APBP2			0.556	3
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.527	2
UniProt:P78371 CCT2	3	CCT2 [cytosol] (R-HSA-390464) CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [extracellular region] (R-HSA-6806220)	0.527	3
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.527	3
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.527	2
UniProt:P62987 UBA52	20	UBA52(1-76) [endocytic vesicle membrane] (R-HSA-939236) Ub-33-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783187) Ub-6-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783072) Ub-11-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783059) Ub-48-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783049) Ub-29-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783030) Ub-27-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783043) Ub-63-UBA52(1-76) [cytosol] (R-HSA-939169) UBA52(1-76) [lysosomal lumen] (R-HSA-9660000) UBA52(1-76) [cytosol] (R-HSA-939203) p-S65-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-9834996) Ub-48-UBA52(1-76) [cytosol] (R-HSA-939250) UBA52(1-76) [mitochondrial outer membrane] (R-HSA-9834955) UBA52(1-76) [late endosome lumen] (R-HSA-9660003) Ub-6-UBA52(1-76) [nucleoplasm] (R-HSA-6782616) Ub-63-UBA52(1-76) [nucleoplasm] (R-HSA-6782530) Ub-48-UBA52(1-76) [nucleoplasm] (R-HSA-5683034) UBA52(1-76) [nucleoplasm] (R-HSA-939844) Ub-63-UBA52(1-76) [plasma membrane] (R-HSA-939851) Ub-63-UBA52(1-76) [endosome membrane] (R-HSA-939185)	0.527	2
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.527	2
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.527	3
UniProt:Q58FG1 HS904			0.527	2

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